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miRNA as New Regulatory Mechanism of Estrogen Vascular Action

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miRNA as New Regulatory Mechanism of Estrogen Vascular Action

dc.contributor.author	Pérez-Cremades, Daniel
dc.contributor.author	Mompeón, Ana
dc.contributor.author	Vidal-Gómez, Xavier
dc.contributor.author	Hermenegildo, Carlos
dc.contributor.author	Novella, Susana
dc.date.accessioned	2020-09-30T15:37:59Z
dc.date.available	2020-09-30T15:37:59Z
dc.date.issued	2018
dc.identifier.citation	Pérez-Cremades, Daniel Mompeón, Ana Vidal-Gómez, Xavier Hermenegildo, Carlos Novella, Susana 2018 miRNA as New Regulatory Mechanism of Estrogen Vascular Action International Journal Of Molecular Sciences 19 473
dc.identifier.uri	https://hdl.handle.net/10550/75705
dc.description.abstract	The beneficial effects of estrogen on the cardiovascular system have been reported extensively. In fact, the incidence of cardiovascular diseases in women is lower than in age-matched men during their fertile stage of life, a benefit that disappears after menopause. These sex-related differences point to sexual hormones, mainly estrogen, as possible cardiovascular protective factors. The regulation of vascular function by estrogen is mainly related to the maintenance of normal endothelial function and is mediated by both direct and indirect gene transcription through the activity of specific estrogen receptors. Some of these mechanisms are known, but many remain to be elucidated. In recent years, microRNAs have been established as non-coding RNAs that regulate the expression of a high percentage of protein-coding genes in mammals and are related to the correct function of human physiology. Moreover, within the cardiovascular system, miRNAs have been related to physiological and pathological conditions. In this review, we address what is known about the role of estrogen-regulated miRNAs and their emerging involvement in vascular biology.
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2018, num. 19 , p. 473
dc.subject	Receptors d'hormones
dc.subject	Genètica
dc.subject	Cèl·lules
dc.title	miRNA as New Regulatory Mechanism of Estrogen Vascular Action
dc.type	journal article	es_ES
dc.date.updated	2020-09-30T15:38:00Z
dc.identifier.doi	10.3390/ijms19020473
dc.identifier.idgrec	130188
dc.rights.accessRights	open access	es_ES