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Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

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Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis

dc.contributor.author	Obrador Plá, Elena
dc.contributor.author	Salvador Palmer, M. del Rosario
dc.contributor.author	López-Blanch, Rafael
dc.contributor.author	Jihad-Jebbar, Ali
dc.contributor.author	Vallés Martí, Lilián Soraya
dc.contributor.author	Estrela Arigüel, Jose María
dc.date.accessioned	2020-10-08T12:10:20Z
dc.date.available	2020-10-08T12:10:20Z
dc.date.issued	2020
dc.identifier.citation	Obrador Plá, Elena Salvador Palmer, M. del Rosario López-Blanch, Rafael Jihad-Jebbar, Ali Vallés Martí, Lilian Soraya Estrela Arigüel, Jose María 2020 Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis Antioxidants 9 (9) E901
dc.identifier.uri	https://hdl.handle.net/10550/75770
dc.description.abstract	Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron (MN) disease. Its primary cause remains elusive, although a combination of different causal factors cannot be ruled out. There is no cure, and prognosis is poor. Most patients with ALS die due to disease-related complications, such as respiratory failure, within three years of diagnosis. While the underlying mechanisms are unclear, different cell types (microglia, astrocytes, macrophages and T cell subsets) appear to play key roles in the pathophysiology of the disease. Neuroinflammation and oxidative stress pave the way leading to neurodegeneration and MN death. ALS-associated mitochondrial dysfunction occurs at different levels, and these organelles are involved in the mechanism of MN death. Molecular and cellular interactions are presented here as a sequential cascade of events. Based on our present knowledge, the discussion leads to the idea that feasible therapeutic strategies should focus in interfering with the pathophysiology of the disease at different steps.
dc.language.iso	eng
dc.relation.ispartof	Antioxidants, 2020, vol. 9, num. (9), p. E901
dc.subject	Patologia
dc.subject	Neurologia
dc.title	Oxidative Stress, Neuroinflammation and Mitochondria in the Pathophysiology of Amyotrophic Lateral Sclerosis
dc.type	journal article	es_ES
dc.date.updated	2020-10-08T12:10:20Z
dc.identifier.doi	10.3390/antiox9090901
dc.identifier.idgrec	140736
dc.rights.accessRights	open access	es_ES