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Virulence of Streptococcus mutans : an intrafamilial cohort study on transmission of genotypes

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Virulence of Streptococcus mutans : an intrafamilial cohort study on transmission of genotypes

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dc.contributor.author Cota, Ana-Lídia-Soares es
dc.contributor.author Silva, Valter es
dc.contributor.author da Silva, Salete-Moura-Bonifácio es
dc.date.accessioned 2020-10-21T09:18:30Z
dc.date.available 2020-10-21T09:18:30Z
dc.date.issued 2020 es
dc.identifier.citation Cota, Ana-Lídia-Soares ; Silva, Valter ; da Silva, Salete-Moura-Bonifácio. Virulence of Streptococcus mutans : an intrafamilial cohort study on transmission of genotypes. En: Journal of Clinical and Experimental Dentistry, 12 1 2020: 59-64 es
dc.identifier.uri https://hdl.handle.net/10550/75982
dc.description.abstract The main aims of this cohort study were to measure the intrafamilial risk of transmission, sharing and stability of the most virulent S. mutans genotypes. A total of 392 clinical isolates of S. mutans obtained from caries-active adults and genotyped to evaluate their transmissibility over time. After extraction of the chromosomal DNA, PCR were performed to detect the genes involved in the production of GbpA (gbpA) and mutacin types I, II, III and IV (mutAI, mutAII, mutAIII and mutAIV). The gbpA, mutAI, mutAII, mutAIII and mutAIV genes were detected in 77.3, 12.5, 51, 16.6 and 89.8% of S. mutans isolates, respectively. The virulence of S. mutans was associated with its transmission (P< 0.01) and stability (P = 0.01), with the most virulent genotypes having higher transmissibility (RR = 1.83, 95% CI 1.44 to 2.32) and higher stability in the oral cavity (RR = 1.52, 95% CI 1.06 to 2.19). Genotypes with the genetic information to synthesize GbpA and mutacins present an important ecological advantage in the process of colonization by S. mutans; they remain stable among the oral microbiota of the host and favor intrafamilial transmission. es
dc.title Virulence of Streptococcus mutans : an intrafamilial cohort study on transmission of genotypes es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.56038 es
dc.type.hasVersion VoR es_ES

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