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RT-qPCR study of COX-1 and -2 genes in oral surgical model comparing single-dose preemptive ibuprofen and etoricoxib : a randomized clinical trialy
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- Journal of Clinical and Experimental Dentistry
- Journal of Clinical and Experimental Dentistry. 2020. Vol. 12, no. 4
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RT-qPCR study of COX-1 and -2 genes in oral surgical model comparing single-dose preemptive ibuprofen and etoricoxib : a randomized clinical trialy
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| dc.contributor.author | Medeiros Albuquerque, Assis Filipe | es |
| dc.contributor.author | Sá Roriz Fonteles, Cristiane | es |
| dc.contributor.author | do Nascimento Costa, José Jackson | es |
| dc.contributor.author | Silva, José Roberto Viana | es |
| dc.contributor.author | Silva, Paulo-Goberlânio-de Barros | es |
| dc.contributor.author | Soares, Eduardo Costa Studart | es |
| dc.contributor.author | Chaves, Filipe Nobre | es |
| dc.contributor.author | Alves Pereira, Karuza Maria | es |
| dc.contributor.author | Rodrigues-Ribeiro, Thyciana | es |
| dc.contributor.author | Gurgel Costa, Fábio Wildson | es |
| dc.date.accessioned | 2020-10-22T11:50:51Z | |
| dc.date.available | 2020-10-22T11:50:51Z | |
| dc.date.issued | 2020 | es |
| dc.identifier.citation | Medeiros Albuquerque, Assis Filipe ; Sá Roriz Fonteles, Cristiane ; do Nascimento Costa, José Jackson ; Silva, José Roberto Viana ; Silva, Paulo-Goberlânio-de Barros ; Soares, Eduardo Costa Studart ; Chaves, Filipe Nobre ; Alves Pereira, Karuza Maria ; Rodrigues-Ribeiro, Thyciana ; Gurgel Costa, Fábio Wildson. RT-qPCR study of COX-1 and -2 genes in oral surgical model comparing single-dose preemptive ibuprofen and etoricoxib : a randomized clinical trialy. En: Journal of Clinical and Experimental Dentistry, 12 4 2020: 371-380 | es |
| dc.identifier.uri | https://hdl.handle.net/10550/76031 | |
| dc.description.abstract | Background: This study aimed to evaluate the gene expression of cyclooxygenases (COXs) in an oral model of preemptive analgesia. Material and Methods: Gingival tissue was collected during extraction of lower third molars from a randomized, triple-blind, split-mouth and placebo-controlled study. The eligible patients were randomly sorted to receive a single dose either of ibuprofen 400mg, or etoricoxib 120 mg or a placebo, one hour prior to surgery. The temporal course of RNAm was evaluated for COX-1 and -2 by means of a quantitative polymerase chain reaction in real time (RT-qPCR) at time zero and 30 minutes after the surgical procedure began, and it was correlated with clinical parameters (pain and maximum mouth opening). Results: There was a significant increase in COX-1 expression between T0 and T30 in ibuprofen (p=0.004) and eto-ricoxib (p=0.010) groups. As regards COX-2, there were increases from T0 to T30 in all groups (placebo, p=0.012; ibuprofen, p<0.001; etoricoxib, p<0.001). All groups showed a significant decrease in COX-2:COX-1 ratio from T0 to T30 (placebo, p=0.013; ibuprofen, p<0.001; etoricoxib, p=0.047). Experimental groups showed a significant correlation between COX-1 and COX-2 levels and clinical pain parameters. Conclusions: The present preemptive analgesia study concludes that COX-2 RNAm induction was directly linked to third molar-related tissue inflammation and that the relation between COX-1 and COX-2 levels were inversely proportional to the preemptively administered nonsteroidal anti-inflammatory drugs COX-2 selectivity. | es |
| dc.title | RT-qPCR study of COX-1 and -2 genes in oral surgical model comparing single-dose preemptive ibuprofen and etoricoxib : a randomized clinical trialy | es |
| dc.type | journal article | es_ES |
| dc.subject.unesco | UNESCO::CIENCIAS MÉDICAS | es |
| dc.identifier.doi | 10.4317/jced.56447 | es |
| dc.type.hasVersion | VoR | es_ES |
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