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Redox modulation of muscle mass and function

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Redox modulation of muscle mass and function

dc.contributor.author	Gómez Cabrera, María Carmen
dc.contributor.author	Arc-Chagnaud, Coralie
dc.contributor.author	Salvador Pascual, A.
dc.contributor.author	Brioche, T.
dc.contributor.author	Chopard, A.
dc.contributor.author	Olaso González, Gloria
dc.contributor.author	Viña Ribes, José
dc.date.accessioned	2020-11-23T09:11:22Z
dc.date.available	2020-11-23T09:11:22Z
dc.date.issued	2020
dc.identifier.citation	Gomez Cabrera, M.C. Arc-Chagnaud, Coralie Salvador Pascual, A. Brioche, T. Chopard, A. Olaso González, Gloria Viña Ribes, José 2020 Redox modulation of muscle mass and function Redox Biology Aug 35 101531
dc.identifier.uri	https://hdl.handle.net/10550/76433
dc.description.abstract	Muscle mass and strength are very important for exercise performance. Training-induced musculoskeletal injuries usually require periods of complete immobilization to prevent any muscle contraction of the affected muscle groups. Disuse muscle wasting will likely affect every sport practitioner in his or her lifetime. Even short periods of disuse results in significant declines in muscle size, fiber cross sectional area, and strength. To understand the molecular signaling pathways involved in disuse muscle atrophy is of the utmost importance to develop more effective countermeasures in sport science research. We have divided our review in four different sections. In the first one we discuss the molecular mechanisms involved in muscle atrophy including the main protein synthesis and protein breakdown signaling pathways. In the second section of the review we deal with the main cellular, animal, and human atrophy models. The sources of reactive oxygen species in disuse muscle atrophy and the mechanism through which they regulate protein synthesis and proteolysis are reviewed in the third section of this review. The last section is devoted to the potential interventions to prevent muscle disuse atrophy with especial consideration to studies on which the levels of endogenous antioxidants enzymes or dietary antioxidants have been tested.
dc.language.iso	eng
dc.relation.ispartof	Redox Biology, 2020, vol. Aug, num. 35, p. 101531
dc.subject	Fisiologia
dc.subject	Fisiologia humana
dc.title	Redox modulation of muscle mass and function
dc.type	journal article	es_ES
dc.date.updated	2020-11-23T09:11:23Z
dc.identifier.doi	10.1016/j.redox.2020.101531
dc.identifier.idgrec	141373
dc.rights.accessRights	open access	es_ES