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A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases lifespan and mobility in C. elegans.

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A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases lifespan and mobility in C. elegans.

dc.contributor.author	Serna García, Eva
dc.contributor.author	Mastaloudis, Angela
dc.contributor.author	Martorell Guerola, Patricia
dc.contributor.author	Wood, Steven M.
dc.contributor.author	Hester, Shelley N.
dc.contributor.author	Bartlett, Mark
dc.contributor.author	Prolla, Tomas A.
dc.contributor.author	Viña Ribes, José
dc.date.accessioned	2020-11-23T10:33:44Z
dc.date.available	2020-11-23T10:33:44Z
dc.date.issued	2020
dc.identifier.citation	Serna Garcia, Eva Mastaloudis, Angela Martorell Guerola, Patricia Wood, Steven M. Hester, Shelley N. Bartlett, Mark Prolla, Tomas A. Viña Ribes, José 2020 A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases lifespan and mobility in C. elegans. Nutrients Feb 14 12 (2) 486
dc.identifier.uri	https://hdl.handle.net/10550/76436
dc.description.abstract	We previously described a novel micronutrient blend that behaves like a putative calorie restriction mimetic. The aim of this paper was to analyze the beneficial effects of our micronutrient blend in mice and C. elegans, and compare them with calorie restriction. Methods: Whole transcriptomic analysis was performed in the brain cortex, skeletal muscle and heart in three groups of mice: old controls (30 months), old + calorie restriction and old + novel micronutrient blend. Longevity and vitality were tested in C. elegans. Results: The micronutrient blend elicited transcriptomic changes in a manner similar to those in the calorie-restricted group and different from those in the control group. Subgroup analysis revealed that nuclear hormone receptor, proteasome complex and angiotensinogen genes, all of which are known to be directly related to aging, were the most affected. Furthermore, a functional analysis in C. elegans was used. We found that feeding C. elegans the micronutrient blend increased longevity as well as vitality. Conclusions: We describe a micronutrient supplement that causes similar changes (transcriptomic and promoting longevity and vitality) as a calorie restriction in mice and C. elegans, respectively, but further studies are required to confirm these effects in humans
dc.language.iso	eng
dc.relation.ispartof	Nutrients, 2020, vol. Feb 14, num. 12 (2), p. 486
dc.subject	Nutrició
dc.title	A novel micronutrient blend mimics calorie restriction transcriptomics in multiple tissues of mice and increases lifespan and mobility in C. elegans.
dc.type	journal article	es_ES
dc.date.updated	2020-11-23T10:33:45Z
dc.identifier.doi	10.3390/nu12020486
dc.identifier.idgrec	137143
dc.rights.accessRights	open access	es_ES