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BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.

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BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.

dc.contributor.author	Borrás, Consuelo
dc.contributor.author	Mas Bargues, Cristina
dc.contributor.author	Román Domínguez, Aurora
dc.contributor.author	Sanz Ros, Jorge
dc.contributor.author	Gimeno Mallench, Lucía
dc.contributor.author	Inglés de la Torre, Marta
dc.contributor.author	Gambini Ricapa, Juan
dc.contributor.author	Viña Ribes, José
dc.date.accessioned	2020-11-24T09:25:00Z
dc.date.available	2020-11-24T09:25:00Z
dc.date.issued	2020
dc.identifier.citation	Borrás, Consuelo Mas Bargues, Cristina Román Domínguez, Aurora Sanz Ros, Jorge Gimeno Mallench, Lucía Inglés de la Torre, Marta Gambini Ricapa, Juan Viña Ribes, José 2020 BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. International Journal Of Molecular Sciences 21 2 E408
dc.identifier.uri	https://hdl.handle.net/10550/76451
dc.description.abstract	B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways can be both beneficial or detrimental depending on the circumstances. Thus, targeting BCL-xL would in turn be a 'double-edge sword' and therefore, additional studies are needed to better comprehend this dual and apparently contradictory role of BCL-XL in longevity. View Full-Text Keywords: healthy aging; apoptosis; autophagy; senescence; longevity; mitochondria
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2020, vol. 21, num. 2, p. E408
dc.subject	Fisiologia humana
dc.title	BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians.
dc.type	journal article	es_ES
dc.date.updated	2020-11-24T09:25:00Z
dc.identifier.doi	10.3390/ijms21020418
dc.identifier.idgrec	137117
dc.rights.accessRights	open access	es_ES