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Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning

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Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning

dc.contributor.author	Arc Chagnaud, Coralie
dc.contributor.author	Py, Guillaume
dc.contributor.author	Fovet, Theo
dc.contributor.author	Roumanille, Remi
dc.contributor.author	Demangel, Remi
dc.contributor.author	Pagano, Allan F.
dc.contributor.author	Delobel, Pierre
dc.contributor.author	Blanc, Stephane
dc.contributor.author	Jasmin, Bernard J.
dc.contributor.author	Blottner, Dieter
dc.contributor.author	Salanova, Michele
dc.contributor.author	Gómez Cabrera, María Carmen
dc.contributor.author	Viña Ribes, José
dc.contributor.author	Brioche, T.
dc.contributor.author	Chopard, A.
dc.date.accessioned	2020-11-24T09:46:58Z
dc.date.available	2020-11-24T09:46:58Z
dc.date.issued	2020
dc.identifier.citation	Arc Chagnaud, Coralie Py, Guillaume Fovet, Theo Roumanille, Remi Demangel, Remi Pagano, Allan F. Delobel, Pierre Blanc, Stephane Jasmin, Bernard J. Blottner, Dieter Salanova, Michele Gomez Cabrera, M.C. Viña Ribes, José Brioche, T. Chopard, A. 2020 Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning Frontiers In Physiology Feb 12 11 71
dc.identifier.uri	https://hdl.handle.net/10550/76452
dc.description.abstract	Understanding the molecular pathways involved in the loss of skeletal muscle mass and function induced by muscle disuse is a crucial issue in the context of spaceflight as well as in the clinical field, and development of efficient countermeasures is needed. Recent studies have reported the importance of redox balance dysregulation as a major mechanism leading to muscle wasting. Our study aimed to evaluate the effects of an antioxidant/anti-inflammatory cocktail (741 mg of polyphenols, 138 mg of vitamin E, 80 μg of selenium, and 2.1 g of omega-3) in the prevention of muscle deconditioning induced by long-term inactivity. The study consisted of 60 days of hypoactivity using the head-down bed rest (HDBR) model. Twenty healthy men were recruited; half of them received a daily antioxidant/anti-inflammatory supplementation, whereas the other half received a placebo. Muscle biopsies were collected from the vastus lateralis muscles before and after bedrest and 10 days after remobilization. After 2 months of HDBR, all subjects presented muscle deconditioning characterized by a loss of muscle strength and an atrophy of muscle fibers, which was not prevented by cocktail supplementation. Our results regarding muscle oxidative damage, mitochondrial content, and protein balance actors refuted the potential protection of the cocktail during long-term inactivity and showed a disturbance of essential signaling pathways (protein balance and mitochondriogenesis) during the remobilization period. This study demonstrated the ineffectiveness of our cocktail supplementation and underlines the complexity of redox balance mechanisms. It raises interrogations regarding the appropriate nutritional intervention to fight against muscle deconditioning.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Physiology, 2020, vol. Feb 12, num. 11, p. 71
dc.subject	Fisiologia humana
dc.title	Evaluation of an Antioxidant and Anti-inflammatory Cocktail Against Human Hypoactivity-Induced Skeletal Muscle Deconditioning
dc.type	journal article	es_ES
dc.date.updated	2020-11-24T09:46:59Z
dc.identifier.doi	10.3389/fphys.2020.00071
dc.identifier.idgrec	141372
dc.rights.accessRights	open access	es_ES