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In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case

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In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case

dc.contributor.author	Gil Castell, O.
dc.contributor.author	Badia Valiente, José David
dc.contributor.author	Ontoria-Oviedo, I.
dc.contributor.author	Castellano, D.
dc.contributor.author	Marco, B.
dc.contributor.author	Rabal, A.
dc.contributor.author	Bou, Jordi
dc.contributor.author	Serra, A.
dc.contributor.author	Monreal, L.
dc.contributor.author	Blanes, M.
dc.contributor.author	Sepúlveda Sanchis, Pilar
dc.contributor.author	Ribes Greus, A.
dc.date.accessioned	2020-12-15T16:06:43Z
dc.date.available	2020-12-15T16:06:43Z
dc.date.issued	2018
dc.identifier.citation	Gil Castell, O. Badia Valiente, José David Ontoria-Oviedo, I. Castellano, D. Marco, B. Rabal, A. Bou, Jordi Serra, A. Monreal, L. Blanes, M. Sepúlveda Sanchis, Pilar Ribes Greus, A. 2018 In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case Polymer Testing 66 256 267
dc.identifier.uri	https://hdl.handle.net/10550/76682
dc.description.abstract	Monitoring and understanding the in vitro behaviour of polyester based scaffolds both comprising the study of the hydrolytic degradation and the cell seeding viability is essential to ensure the desired functionality, according to a given biomedical purpose. As a model case to compare the performance of techniques to monitor the in vitro behaviour, poly(lactide-co-glycolide) (PLGA) scaffolds were chosen. The in vitro hydrolytic degradation of PLGA scaffolds was carried out in water and phosphate buffered saline (PBS). The evolution of the mass loss, the molar mass, the thermal properties and the surface morphology were monitored. The hydrolytic degradation media was correspondingly evaluated by means of the study of the pH, the amount of acid released and the conductivity. In addition, the in vitro biocompatibility regarding the cell culture viability was studied under physiological conditions. The cellular adhesion, cellular ability to proliferate on the scaffold, the scaffold inflammatory profile and the effect of the scaffold degradation compounds on the cells were assessed. A comparative analysis of the exploited techniques in terms of promptness of identification, depth of knowledge, simplicity of obtaining results and cost of the technique was implemented. The results showed that, depending on the balance between the interest in ascertaining the trigger of degradation or deep into the knowledge of the causes and effects of cell culture viability, an appropriate plan of analysis of the validation of polyester-based scaffolds could be designed.
dc.language.iso	eng
dc.relation.ispartof	Polymer Testing, 2018, vol. 66, p. 256-267
dc.subject	Solucions polimèriques
dc.subject	Materials
dc.title	In vitro validation of biomedical polyester-based scaffolds: Poly(lactide-co-glycolide) as model-case
dc.type	journal article	es_ES
dc.date.updated	2020-12-15T16:06:43Z
dc.identifier.doi	10.1016/j.polymertesting.2018.01.027
dc.identifier.idgrec	132230
dc.rights.accessRights	open access	es_ES