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Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study

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Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study

dc.contributor.author	Perdomo-Lara, Sandra Janeth	es
dc.contributor.author	Buenahora, María Rosa	es
dc.contributor.author	Alvarez Martínez, Efraín	es
dc.contributor.author	González Martínez, Farith	es
dc.contributor.author	Rebolledo Cobos, Martha	es
dc.contributor.author	Aristizábal Gutiérrez, Fabio Ancízar	es
dc.contributor.author	Colegial, Carlos Humberto	es
dc.contributor.author	Horta, Alvaro	es
dc.contributor.author	Bustillo Rojas, Jairo Alberto	es
dc.contributor.author	Díaz Báez, David	es
dc.contributor.author	Ardila Medina, Carlos Martín	es
dc.contributor.author	Lafaurie Villamil, Gloria Inés	es
dc.date.accessioned	2021-01-14T10:11:34Z
dc.date.available	2021-01-14T10:11:34Z
dc.date.issued	2020	es
dc.identifier.citation	Perdomo-Lara, Sandra Janeth ; Buenahora, María Rosa ; Alvarez Martínez, Efraín ; González Martínez, Farith ; Rebolledo Cobos, Martha ; Aristizábal Gutiérrez, Fabio Ancízar ; Colegial, Carlos Humberto ; Horta, Alvaro ; Bustillo Rojas, Jairo Alberto ; Díaz Báez, David ; Ardila Medina, Carlos Martín ; Lafaurie Villamil, Gloria Inés. Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 1 2020: 1-	es
dc.identifier.uri	https://hdl.handle.net/10550/77072
dc.description.abstract	Oral cancer associated with high risk (HPV-HR) human papilloma virus (HPV) has been increasing. HPV-HR has been associated with epithelial dysplasia, however, little information exists on its frequency in epithelial hyperplasia lesions. The aim of this study is to compare HPV genotypes in dysplastic and hyperplastic lesions of oral cavity. Two hundred and fifty oral lesions: 131 dysplasia and 119 hyperplasia from two regions of Colombia were evaluated. One hundred seventy-four coming from urban area and 104 from a high risk population to oral cancer from a rural area. HPV was identified by qPCR and Twenty-four HPVs genotypes were evaluated by Luminex® technology. Logistic regressions were performed to establish the associations between HPV infections with oral dysplasia. Twenty-eight percent (70/250) of the samples were positives for any HPV and HPV-HRs were more frequently than low risk HPVs. HPV-16 was the most detected genotype (16%) followed by HPV-31, 53, 18 and 45. HPV, HPV-HRs and HPV-16 were only associated with dysplasia in urban area; OR 3.28 (CI 95% 1.49-7.17), OR 7.94 (CI 95% 2.97-21.2) and OR 5.90 (CI 95% 2.05-17). Individuals in rural area showed more HPV and HPV-HRs infection in hyperplasic lesions than urban population. The majority of HPV+ lesions had multi-type of HPV (52/70) and the urban individuals showed more genotypes than rural population. HPV-.HRs are frequently found in hyperplastic and dysplastic epithelial lesions. HPV-HRs and HPV-16 were associated with dysplasia in urban population. Rural high risk population and urban population differ in the frequency and variety of HPV genotypes.	es
dc.title	Human papilloma virus genotypes in dysplasia and epithelial hyperplasia of oral cavity using the luminex xmap technology. A multicenter study	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23188	es
dc.type.hasVersion	VoR	es_ES