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Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis

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Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis

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dc.contributor.author Santana, Thalita es
dc.contributor.author Matuck, Bruno es
dc.contributor.author Tenorio, Jefferson-da-Rocha es
dc.contributor.author Braga, Mariana Minatel es
dc.date.accessioned 2021-01-14T10:11:36Z
dc.date.available 2021-01-14T10:11:36Z
dc.date.issued 2020 es
dc.identifier.citation Santana, Thalita ; Matuck, Bruno ; Tenorio, Jefferson-da-Rocha ; Braga, Mariana Minatel. Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 1 2020: 6- es
dc.identifier.uri https://hdl.handle.net/10550/77076
dc.description.abstract Actinic cheilitis (AC) is a poten-tially malignant disorder of the lip, characterized by epithelial and connective tissue alterations caused by chronic exposure to ultraviolet radiation. In the past decades, diverse studies have been conducted in lip carcinogenesis and many biomarkers have been identified in lip lesions, yet there is no scientific evidence that determines its usefulness in the clinical setting or in histopatho-logical routine. Therefore, we conducted the first systematic review in this field to summarize the results of published studies on immunohistochemical bi-omarkers in lip carcinogenesis, to evaluate if there is a marker than can distin-guish the different histological grades of AC. Retrospective stud-ies that investigated immunohistochemical biomarkers in AC defined on standardised histological assessment were gathered from five databases and evaluated. Each study was qualitatively evaluated using the Critical Appraisal Tools from SUMARI. The proliferation marker Ki-67 was the most studied biomarker and we observed, through meta-analysis, that it was differently expressed between AC and lip cancer, but not in AC sub-groups. Most articles had a high risk of bias. In summary, the literature lacks quality follow up studies in actinic cheilitis. Multi-centre cohort studies, with patients stratified by treatment type and the use of image analysis soft-ware, could be the solution to further address the issues of investigating poten-tially malignant lesions and help change clinical practice, in terms of individu-alizing patients? treatment and prognosis prediction. es
dc.title Can immunohistochemical biomarkers distinguish epithelial dysplasia degrees in actinic cheilitis? A systematic review and meta-analysis es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23223 es
dc.type.hasVersion VoR es_ES

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