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CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

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CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma

dc.contributor.author	da Silva, Luan César	es
dc.contributor.author	Fonseca, Felipe Paiva	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Mariz, Bruno A.L.A.	es
dc.contributor.author	Lopes, Márcio Ajudarte	es
dc.contributor.author	Radhakrishnan, Raghu A.	es
dc.contributor.author	Sharma, Mohit	es
dc.contributor.author	Kowalski, Luiz Paulo	es
dc.contributor.author	Vargas, Pablo Agustín	es
dc.date.accessioned	2021-01-14T10:11:39Z
dc.date.available	2021-01-14T10:11:39Z
dc.date.issued	2020	es
dc.identifier.citation	da Silva, Luan César ; Fonseca, Felipe Paiva ; Almeida, Oslei Paes de ; Mariz, Bruno A.L.A. ; Lopes, Márcio Ajudarte ; Radhakrishnan, Raghu A. ; Sharma, Mohit ; Kowalski, Luiz Paulo ; Vargas, Pablo Agustín. CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 1 2020: 14-	es
dc.identifier.uri	https://hdl.handle.net/10550/77084
dc.description.abstract	The objective of this study investigated the distribution of immature dendritic cells (DCs), Langerhans cells and plasmacytoid DCs in oral submucous fibrosis (OSMF), OSMF associated with oral squamous cell carcinoma (OSMF-OSCC), oral leukoplakia (OL), and oral squamous cell carcinoma (OSCC). Fourteen cases of OSMF, 9 of OSMF-OSCC, 8 of OL¸ 45 of OSCC and 8 of normal epithelium were retrospectively retrieved and their diagnoses confirmed. Immunoreactions against CD1a, CD207 e CD303 were performed and the number of positive cells quantified. A significant decrease of CD1a+ was found in OSMF (p?0.05), OSMF-OSCC (p ? 0.01), and OSCC (p ? 0.001) when compared to normal epithelium. For CD207+ the significance decrease was observed in OSMF-OSCC (p ? 0.05), and OSCC (p ? 0.01) when compared with normal epithelium, and in OSMF when compared with OL (p ? 0.05). There was no significant difference for CD303, but increased in CD303+ was observed in OSCC when compared with normal epithelium. The decrease in the number of CD1a+ and CD207+ cells may be associate to the development of oral OSCC, and in OPMDs they might be indicators of malignant transformation.	es
dc.title	CD1a+ and CD207+ cells are reduced in oral submucous fibrosis and oral squamous cell carcinoma	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23177	es
dc.type.hasVersion	VoR	es_ES