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SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma

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SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma

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dc.contributor.author de Freitas Silva, Brunno Santos es
dc.contributor.author Silva, Lorena Rosa es
dc.contributor.author de Lima, Kaique Leite es
dc.contributor.author dos Santos, Amanda Cristina Ferreira es
dc.contributor.author Oliveira, Anna Carolina es
dc.contributor.author Dezzen-Gomide, Ana Cláudia es
dc.contributor.author Batista, Aline Carvalho es
dc.contributor.author Yamamoto, Fernanda-Paula es
dc.date.accessioned 2021-01-14T10:49:17Z
dc.date.available 2021-01-14T10:49:17Z
dc.date.issued 2020 es
dc.identifier.citation de Freitas Silva, Brunno Santos ; Silva, Lorena Rosa ; de Lima, Kaique Leite ; dos Santos, Amanda Cristina Ferreira ; Oliveira, Anna Carolina ; Dezzen-Gomide, Ana Cláudia ; Batista, Aline Carvalho ; Yamamoto, Fernanda-Paula. SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 2 2020: 1- es
dc.identifier.uri https://hdl.handle.net/10550/77096
dc.description.abstract The purpose of this experimental study was to compare the immunohistochemical expression of SOX2 and BCL-2 in Odontogenic Keratocyst (OKC) and Ameloblastoma (AB) specimens, and to identify a possible correlation in their expression. Immunohistochemical analysis was performed to evaluate SOX2 and BCL-2 expression in OKC (n = 20) and AB (n = 20). The immunoexpression was analyzed by a quantitative and qualitative scoring system. The comparison between the immunoexpression of SOX 2 and BCL-2 was assessed by the Mann-Whitney U-test. Spearman?s correlation coefficient evaluated the correlation between SOX2 and BCL-2 expressions. SOX2 and BCL-2 expression was observed in all specimens of OKC in the full thickness of the epithelium lining. SOX2 immunostaining was higher in OKC, in comparison with AB samples (P<0.05). BCL-2 immunostaining between OKC and AB was not statistically significant. There was no significant correlation between SOX2 and BCL-2 in OKC and AB specimens. SOX2 and BCL-2 expressions in OKC may suggest their relationship with the biological behavior of this lesion, and the higher expression of SOX2 might be an upstream influence on the Hh signaling pathway. es
dc.title SOX2 and BCL-2 Expressions in Odontogenic Keratocyst and Ameloblastoma es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23348 es
dc.type.hasVersion VoR es_ES

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