NAGIOS: RODERIC FUNCIONANDO

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic review

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic review

Mostra el registre parcial de l'element

dc.contributor.author de Morais, Everton Freitas es
dc.contributor.author Pinheiro, Juliana Campos es
dc.contributor.author Lira, Jadson Alexandre Silva es
dc.contributor.author Mafra, Rodrigo Porpino es
dc.contributor.author Barboza, Carlos Augusto Galvão es
dc.contributor.author Souza, Lélia Batista de es
dc.contributor.author Freitas, Roseana A. es
dc.date.accessioned 2021-01-14T10:49:21Z
dc.date.available 2021-01-14T10:49:21Z
dc.date.issued 2020 es
dc.identifier.citation de Morais, Everton Freitas ; Pinheiro, Juliana Campos ; Lira, Jadson Alexandre Silva ; Mafra, Rodrigo Porpino ; Barboza, Carlos Augusto Galvão ; Souza, Lélia Batista de ; Freitas, Roseana A.. Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic review. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 2 2020: 10- es
dc.identifier.uri https://hdl.handle.net/10550/77105
dc.description.abstract Oral potentially malignant disorders (OPMDs) comprise a range of clinical-pathological alterations that are frequently characterized as architectural and cytological derangements upon histological analysis. Epithelial-mesenchymal transition (EMT) has been proposed as a critical mechanism for the acquisition of the malignant phenotype in neoplastic epithelial processes. This study aims to systematically review the current findings on the immunohistochemical expression of epithelial-mesenchymal transition markers in oral potentially malignant disorders and to evaluate their possible application as biomarkers associated with the progression of oral epithelial dysplasias. A systematic search was performed in the following databases: PubMed, EMBASE, Chinese BioMedical Literature Database, and Cochrane Library. Articles that evaluated the relationship between the expression of EMT markers and the degree of oral epithelial dysplasia were selected for the systematic review. The quality of each eligible study was evaluated by independent reviewers that used operationalized prognostic biomarker reporting guidelines (REMARK). Seventeen articles met all inclusion criteria and were selected. The EMT markers analyzed exhibited an important association with the prognosis of the cases evaluated. The results showed a progressive increase in the expression of nuclear transcription factors and markers of mesenchymal differentiation, as well as negative regulation of epithelial and cell adhesion markers, according to the stage of oral epithelial dysplasia. The dysregulation of expression of important EMT components in oral dysplastic epithelium is a potential prognostic marker in OPMDs. es
dc.title Prognostic value of the immunohistochemical detection of epithelial-mesenchymal transition biomarkers in oral epithelial dysplasia : a systematic review es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/medoral.23305 es
dc.type.hasVersion VoR es_ES

Visualització       (835.5Kb)

Aquest element apareix en la col·lecció o col·leccions següent(s)

Mostra el registre parcial de l'element

Cerca a RODERIC

Cerca avançada

Visualitza

Estadístiques