NAGIOS: RODERIC FUNCIONANDO

Use of Silica Based Materials as Modulators of the Lipase Catalyzed Hydrolysis of Fats under Simulated Duodenal Conditions

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Use of Silica Based Materials as Modulators of the Lipase Catalyzed Hydrolysis of Fats under Simulated Duodenal Conditions

dc.contributor.author	Muñoz-Pina, Sara
dc.contributor.author	Amorós del Toro, Pedro José
dc.contributor.author	El Haskouri, Jamal
dc.contributor.author	Andrés, Ana
dc.contributor.author	Ros-Lis, José Vicente
dc.date.accessioned	2021-03-04T14:36:22Z
dc.date.available	2021-03-04T14:36:22Z
dc.date.issued	2020
dc.identifier.citation	Muñoz-Pina, Sara Amorós del Toro, Pedro José El Haskouri, Jamal Andrés, Ana Ros-Lis, José Vicente 2020 Use of Silica Based Materials as Modulators of the Lipase Catalyzed Hydrolysis of Fats under Simulated Duodenal Conditions Nanomaterials 10 1927
dc.identifier.uri	https://hdl.handle.net/10550/78163
dc.description.abstract	The effect of silica materials and their functionalization in the lipase catalyzed fat hydrolysis has been scarcely studied. Fifteen silica materials were prepared and their effect on the fat hydrolysis was measured, under simulated duodenal conditions, using the pH-stat method. The materials are composed of the combination of three supports (Stöber massive silica nanoparticles, Stöber mesoporous nanoparticles and UVM-7) and four surface functionalizations (methyl, trimethyl, propyl and octyl). In addition, the non-functionalized materials were tested. The functional groups were selected to offer a hydrophobic character to the material improving the interaction with the fat globules and the lipase. The materials are able to modulate the lipase activity and their effect depending on the support topology and the organic covering, being able to increase or reduce the fat hydrolysis. Depending of the material, relative fat hydrolysis rates of 75 to 140% in comparison with absence of the material were obtained. The results were analyzed by Partial Least Square Regression and suggest that the alkyl modified mesopores are able to improve the fat hydrolysis, by contrast the non-porous nanoparticles and the textural pores tend to induce inhibition. The effects are more pronounced for materials containing long alkyl chains and/or in absence of taurodeoxycholate.
dc.language.iso	eng
dc.relation.ispartof	Nanomaterials, 2020, vol. 10, num. 1927
dc.subject	Materials nanoestructurats
dc.subject	Nanotecnologia
dc.subject	Enzims
dc.title	Use of Silica Based Materials as Modulators of the Lipase Catalyzed Hydrolysis of Fats under Simulated Duodenal Conditions
dc.type	journal article	es_ES
dc.date.updated	2021-03-04T14:36:22Z
dc.identifier.doi	10.3390/nano10101927
dc.identifier.idgrec	143625
dc.rights.accessRights	open access	es_ES