NAGIOS: RODERIC FUNCIONANDO

Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.

Repositori DSpace/Manakin

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.

dc.contributor.author	Marí Alexandre, Josep
dc.contributor.author	Carcelén Pellín, Antonio
dc.contributor.author	Agababyan, Cristina
dc.contributor.author	Moreno Manuel, Andrea
dc.contributor.author	García Oms, Javier
dc.contributor.author	Calabuig Fariñas, Silvia
dc.contributor.author	Gilabert Estellés, Juan
dc.date.accessioned	2021-03-09T12:25:06Z
dc.date.available	2021-03-09T12:25:06Z
dc.date.issued	2019
dc.identifier.citation	Marí Alexandre, Josep Carcelén Pellín, Antonio Agababyan, Cristina Moreno Manuel, Andrea García Oms, Javier Calabuig Fariñas, Silvia Gilabert Estellés, Juan 2019 Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis. International Journal Of Molecular Sciences 20 21 pii: E5322
dc.identifier.uri	https://hdl.handle.net/10550/78213
dc.description.abstract	Ovarian cancer and endometriosis are two distinct gynaecological conditions that share many biological aspects incuding proliferation, invasion of surrounding tissue, inflammation, inhibition of apoptosis, deregulation of angiogenesis and the ability to spread at a distance. miRNAs are small non-coding RNAs (19-22 nt) that act as post-transcriptional modulators of gene expression and are involved in several of the aforementioned processes. In addition, a growing body of evidence supports the contribution of oxidative stress (OS) to these gynaecological diseases: increased peritoneal OS due to the decomposition of retrograde menstruation blood facilitates both endometriotic lesion development and fallopian tube malignant transformation leading to high-grade serous ovarian cancer (HGSOC). Furthermore, as HGSOC develops, increased OS levels are associated with chemoresistance. Finally, continued bleeding within ovarian endometrioma raises OS levels and contributes to the development of endometriosis-associated ovarian cancer (EAOC). Therefore, this review aims to address the need for a better understanding of the dialogue between miRNAs and oxidative stress in the pathophysiology of ovarian conditions: endometriosis, EAOC and HGSOC
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2019, vol. 20, num. 21, p. pii: E5322
dc.subject	Ginecologia
dc.subject	Càncer
dc.title	Interplay Between MicroRNAs and Oxidative Stress in Ovarian Conditions with a Focus on Ovarian Cancer and Endometriosis.
dc.type	journal article	es_ES
dc.date.updated	2021-03-09T12:25:06Z
dc.identifier.doi	10.3390/ijms20215322
dc.identifier.idgrec	136076
dc.rights.accessRights	open access	es_ES