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Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis

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Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis

dc.contributor.author	Mompeon, Ana
dc.contributor.author	Ortega-Paz, Luis
dc.contributor.author	Vidal-Gómez, Xavier
dc.contributor.author	Januario Costa, Tiago
dc.contributor.author	Pérez Cremades, Daniel
dc.contributor.author	Garcia-Blas, Sergio
dc.contributor.author	Brugaletta, Salvatore
dc.contributor.author	Sanchis, Juan
dc.contributor.author	Sabate, Manel
dc.contributor.author	Novella, Susana
dc.contributor.author	Dantas, A.P.
dc.contributor.author	Hermenegildo, Carlos
dc.date.accessioned	2021-04-13T07:06:40Z
dc.date.available	2021-04-13T07:06:40Z
dc.date.issued	2020
dc.identifier.citation	Mompeon, Ana Ortega-Paz, Luis Vidal-Gómez, Xavier Januario Costa, Tiago Pérez Cremades, Daniel Garcia-Blas, Sergio Brugaletta, Salvatore Sanchis, Juan Sabate, Manel Novella, Susana Dantas, A.P. Hermenegildo, Carlos 2020 Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis Scientific Reports 25 10 5373
dc.identifier.uri	https://hdl.handle.net/10550/78582
dc.description.abstract	Despite the promising value of miRNAs in the diagnostic and prognostic of cardiovascular disease (CVD), recent meta-analyses did not support their potential. Methodological variances in studies may interfere with miRNA profle and afect their results. This study determines if the blood starting material is a source of variance in miRNA profle by performing a paired comparison in plasma and serum of the expression of primary miRNAs associated with CVD. Circulating miRNA yield was similar in both plasma and serum, although a signifcant increase was observed in patients with Non-ST-elevation myocardial infarction (NSTEMI) compared to control volunteers. When normalized by the expression of miR-484, diferent patterns of miRNA expression between serum and plasma. Although NSTEMI modifed the expression of miR-1 and miR-208 in both serum and plasma, plasma displayed a higher variance than serum (Levene's test p<0.01). For miR-133a and miR-26a, diferences were only detected in serum (p=0.0240), and conversely, miR-499a showed diferences only in plasma of NSTEMI (p=0.001). Interestingly, miR-21 showed an opposite pattern of expression, being increased in serum (2−ΔΔCt:5.7, p=0.0221) and decreased in plasma (2−ΔΔCt: 0.5, p=0.0107). Plasma and serum exhibit diferent patterns of circulating miRNA expression in NSTEMI and suggest that results from studies with diferent starting material could not be comparable.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2020, vol. 25 , num. 10, p. 5373
dc.subject	Cor
dc.subject	Fisiologia
dc.title	Disparate miRNA expression in serum and plasma of patients with acute myocardial infarction: a systematic and paired comparative analysis
dc.type	journal article	es_ES
dc.date.updated	2021-04-13T07:06:40Z
dc.identifier.doi	10.1038/s41598-020-61507-z
dc.identifier.idgrec	136635
dc.rights.accessRights	open access	es_ES