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MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma

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MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma

dc.contributor.author	Pattanayak, Chaudhuri Birlipta
dc.contributor.author	Garrido-Cano, Iris
dc.contributor.author	Adam-Artigues, Anna
dc.contributor.author	Tormo, Eduardo
dc.contributor.author	Pineda Merlo, Begoña
dc.contributor.author	Cabello, Paula
dc.contributor.author	Alonso, Elisa
dc.contributor.author	Bermejo, Begoña
dc.contributor.author	Hernando, Cristina
dc.contributor.author	Martínez Martínez, María Teresa
dc.contributor.author	Rovira, Ana
dc.contributor.author	Albanell, Joan
dc.contributor.author	Rojo, Federico
dc.contributor.author	Burgues Gasión, Octavio
dc.contributor.author	Cejalvo Andújar, Juan Miguel
dc.contributor.author	Lluch Hernández, Ana
dc.contributor.author	Eroles Asensio, Pilar
dc.date.accessioned	2021-04-15T15:33:26Z
dc.date.available	2021-04-15T15:33:26Z
dc.date.issued	2020
dc.identifier.citation	Pattanayak, Chaudhuri Birlipta Garrido-Cano, Iris Adam-Artigues, Anna Tormo, Eduardo Pineda Merlo, Begoña Cabello, Paula Alonso, Elisa Bermejo, Begoña Hernando, Cristina Martínez Martínez, María Teresa Rovira, Ana Albanell, Joan Rojo, Federico Burgues Gasión, Octavio Cejalvo Andújar, Juan Miguel Lluch Hernández, Ana Eroles Asensio, Pilar 2020 MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma Frontiers In Oncology 10 1661 1661
dc.identifier.uri	https://hdl.handle.net/10550/78689
dc.description.abstract	Downregulation of miR-33b has been documented in many types of cancers and is being involved in proliferation, migration, and epithelial-mesenchymal transition (EMT). Furthermore, the enhancer of zeste homolog 2-gene (EZH2) is a master regulator of controlling the stem cell differentiation and the cell proliferation processes. We aim to evaluate the implication of miR-33b in the EMT pathway in HER2+ breast cancer (BC) and to analyze the role of EZH2 in this process as well as the interaction between them. miR-33b is downregulated in HER2+ BC cells vs healthy controls, where EZH2 has an opposite expression in vitro and in patients' samples. The upregulation of miR-33b suppressed proliferation, induced apoptosis, reduced invasion, migration and regulated EMT by an increase of E-cadherin and a decrease of ß-catenin and vimentin. The silencing of EZH2 mimicked the impact of miR-33b overexpression. Furthermore, the inhibition of miR-33b induces cell proliferation, invasion, migration, EMT, and EZH2 expression in non-tumorigenic cells. Importantly, the Kaplan-Meier analysis showed a significant association between high miR-33b expression and better overall survival. These results suggest miR-33b as a suppressive miRNA that could inhibit tumor metastasis and invasion in HER2+ BC partly by impeding EMT through the repression of the MYC-EZH2 loop.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Oncology, 2020, vol. 10, p. 1661-1661
dc.subject	Càncer
dc.subject	Mama Examen
dc.title	MicroRNA-33b Suppresses Epithelial-Mesenchymal Transition Repressing the MYC-EZH2 Pathway in HER2+ Breast Carcinoma
dc.type	journal article	es_ES
dc.date.updated	2021-04-15T15:33:26Z
dc.identifier.doi	10.3389/fonc.2020.01661
dc.identifier.idgrec	142836
dc.rights.accessRights	open access	es_ES