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Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study

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Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study

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dc.contributor.author Rodrigues, Mariana-Sudati es
dc.contributor.author Kaefer, Eduardo-Oliveira es
dc.contributor.author Sganzerla, Juliana-Tomaz es
dc.contributor.author Gassen, Humberto-Thomazi es
dc.contributor.author dos Santos, Rubem-Beraldo es
dc.contributor.author Miguens-Jr, Sergio-Augusto-Quevedo es
dc.date.accessioned 2021-04-19T10:42:37Z
dc.date.available 2021-04-19T10:42:37Z
dc.date.issued 2020 es
dc.identifier.citation Rodrigues, Mariana-Sudati ; Kaefer, Eduardo-Oliveira ; Sganzerla, Juliana-Tomaz ; Gassen, Humberto-Thomazi ; dos Santos, Rubem-Beraldo ; Miguens-Jr, Sergio-Augusto-Quevedo. Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study. En: Journal of Clinical and Experimental Dentistry, 12 10 2020: 944-950 es
dc.identifier.uri https://hdl.handle.net/10550/78780
dc.description.abstract Actinic Cheilitis (AC) is a pathological condition of the labial mucosa considered potentially malignant. The aim of this study was to investigate the effect of treatment of AC with daily use of a vitamin-based barrier cream. For this clinical study, 36 participants with lower-lip AC were recruited from three oral medicine services. At baseline, participants were evaluated by clinical examination and clinical severity of AC was classified as grade I to IV. All participants were dispensed a tube of a barrier cream containing vitamins A, D, E and ZnO to apply once nightly for 90 consecutive days. Monthly follow-up was performed to reclassify AC clinial severity. The primary outcome of interest was clinical remission of AC at 90-day follow-up compared to baseline. Progressive remission of AC lesions was observed as early as the first month and throughout the assessment period (p = 0.000). The 3-month period was insufficient for remission of lesions, especially among male participants (p = 0.002) and with a longer sun exposure in years (p = 0.007). Daily use of the vitamin-based barrier cream had a promissing positive impact on the severity of actinic cheilitis. However, a 90-day course of treatment was not sufficient to achieve lesions remission. The findings of this study suggest a promising new avenue for the treatment of lower-lip AC. es
dc.title Evaluation of effect of a vitamin-based barrier cream on the clinical severity of actinic cheilitis : a preliminary study es
dc.type journal article es_ES
dc.subject.unesco UNESCO::CIENCIAS MÉDICAS es
dc.identifier.doi 10.4317/jced.57013 es
dc.type.hasVersion VoR es_ES

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