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Eukaryotic RNA Polymerases: the many ways to transcribe a gene

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Eukaryotic RNA Polymerases: the many ways to transcribe a gene

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dc.contributor.author Barba-Aliaga, Marina
dc.contributor.author Alepuz Martínez, Paula
dc.contributor.author Pérez Ortín, José Enrique
dc.date.accessioned 2021-04-21T16:05:32Z
dc.date.available 2021-04-21T16:05:32Z
dc.date.issued 2021
dc.identifier.citation Barba-Aliaga, Marina Alepuz Martínez, Paula Pérez Ortín, José Enrique 2021 Eukaryotic RNA Polymerases: the many ways to transcribe a gene Frontiers In Molecular Biosciences 8 663209
dc.identifier.uri https://hdl.handle.net/10550/78873
dc.description.abstract In eukaryotic cells, three nuclear RNA polymerases (RNA pols) carry out the transcription from DNA to RNA, and they all seem to have evolved from a single enzyme present in the common ancestor with archaea. The multiplicity of eukaryotic RNA pols allows each one to remain specialized in the synthesis of a subset of transcripts, which are different in the function, length, cell abundance, diversity, and promoter organization of the corresponding genes. We hypothesize that this specialization of RNA pols has conditioned the evolution of the regulatory mechanisms used to transcribe each gene subset to cope with environmental changes. We herein present the example of the homeostatic regulation of transcript levels versus changes in cell volume. We propose that the diversity and instability of messenger RNAs, transcribed by RNA polymerase II, have conditioned the appearance of regulatory mechanisms based on different gene promoter strength and mRNA stability. However, for the regulation of ribosomal RNA levels, which are very stable and transcribed mainly by RNA polymerase I from only one promoter, different mechanisms act based on gene copy variation, and a much simpler regulation of the synthesis rate.
dc.language.iso eng
dc.relation.ispartof Frontiers In Molecular Biosciences, 2021, vol. 8, num. 663209
dc.subject RNA
dc.subject Cèl·lules eucariotes
dc.title Eukaryotic RNA Polymerases: the many ways to transcribe a gene
dc.type journal article es_ES
dc.date.updated 2021-04-21T16:05:32Z
dc.identifier.doi 10.3389/fmolb.2021.663209
dc.identifier.idgrec 145517
dc.rights.accessRights open access es_ES

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