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FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

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FOXP2 expression and gray matter density in the male brains of patients with schizophrenia

dc.contributor.author	Sanjuán Arias, Julio
dc.contributor.author	Castro-Martínez, Xochitl Helga
dc.contributor.author	García Martí, Gracián
dc.contributor.author	González-Fernández, Javier
dc.contributor.author	Sanz-Requena, Roberto
dc.contributor.author	Haro, Josep María
dc.contributor.author	Meana, J. Javier
dc.contributor.author	Martí Bonmatí, Luis
dc.contributor.author	Nácher Roselló, Juan Salvador
dc.contributor.author	Sebastiá Ortega, Noelia
dc.contributor.author	Gilabert Juan, Javier
dc.contributor.author	Moltó Ruiz, María Dolores
dc.date.accessioned	2021-04-23T14:16:56Z
dc.date.available	2021-04-23T14:16:56Z
dc.date.issued	2020
dc.identifier.citation	Sanjuán Arias, Julio Castro-Martínez, Xochitl Helga García Martí, Gracián González-Fernández, Javier Sanz-Requena, Roberto Haro, Josep María Meana, J. Javier Martí Bonmatí, Luis Nácher Roselló, Juan Salvador Sebastiá Ortega, Noelia Gilabert Juan, Javier Moltó Ruiz, María Dolores 2020 FOXP2 expression and gray matter density in the male brains of patients with schizophrenia Brain Imaging And Behavior
dc.identifier.uri	https://hdl.handle.net/10550/78903
dc.description.abstract	Common genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression of FOXP2 and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure. FOXP2 expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences in FOXP2 expression and brain morphometry depending on the rs2396753, relating low FOXP2 mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and low FOXP2 expression comparing with the heterozygous controls.This study shows the importance of independent replication of neuroimaging genetic studies of FOXP2 as a candidate gene in schizophrenia. Furthermore, our results suggest that the FOXP2 rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia.
dc.language.iso	eng
dc.relation.ispartof	Brain Imaging And Behavior, 2020
dc.subject	Sistema nerviós central Malalties
dc.subject	Esquizofrènia
dc.title	FOXP2 expression and gray matter density in the male brains of patients with schizophrenia
dc.type	journal article	es_ES
dc.date.updated	2021-04-23T14:16:56Z
dc.identifier.doi	10.1007/s11682-020-00339-x
dc.identifier.idgrec	141045
dc.rights.accessRights	open access	es_ES