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The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress

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The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress

dc.contributor.author	Méndez Belinchón, Ester
dc.contributor.author	Gomar Alba, Mercè
dc.contributor.author	Bañó Aracil, María del Carmen
dc.contributor.author	Mendoza, Manuel
dc.contributor.author	Quilis Bayarri, Inmaculada
dc.contributor.author	Igual García, Juan Carlos
dc.date.accessioned	2021-05-03T14:27:08Z
dc.date.available	2021-05-03T14:27:08Z
dc.date.issued	2020
dc.identifier.citation	Méndez Belinchón, Ester Gomar Alba, Mercè Bañó Aracil, María del Carmen Mendoza, Manuel Quilis Bayarri, Inmaculada Igual García, Juan Carlos 2020 The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress Journal of Cell Science 133 24
dc.identifier.uri	https://hdl.handle.net/10550/79023
dc.description.abstract	Start is the main decision point in the eukaryotic cell cycle at which cells commit to a new round of cell division. It involves the irreversible activation of a transcriptional programme through the inactivation of Start transcriptional repressors: the retinoblastoma family in mammals, or Whi5 and its recently identified paralogue Whi7 (also known as Srl3) in budding yeast. Here, we provide a comprehensive comparison of Whi5 and Whi7 that reveals significant qualitative differences. Indeed, the expression, subcellular localization and functionality of Whi7 and Whi5 are differentially regulated. Importantly, Whi7 shows specific properties in its association with promoters not shared by Whi5, and for the first time, we demonstrate that Whi7, and not Whi5, can be the main contributor to Start inhibition such as it occurs in the response to cell wall stress. Our results help to improve understanding of the interplay between multiple differentially regulated Start repressors in order to face specific cellular conditions.
dc.language.iso	eng
dc.relation.ispartof	Journal of Cell Science, 2020, vol. 133, num. 24
dc.subject	Cicle cel·lular
dc.subject	Cèl·lules eucariotes
dc.title	The budding yeast Start repressor Whi7 differs in regulation from Whi5, emerging as a major cell cycle brake in response to stress
dc.type	journal article	es_ES
dc.date.updated	2021-05-03T14:27:09Z
dc.identifier.doi	10.1242/jcs.251413
dc.identifier.idgrec	142166
dc.rights.accessRights	open access	es_ES