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Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

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Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.

dc.contributor.author	Erzin, G.
dc.contributor.author	Pries, L.K.
dc.contributor.author	van Os, J.
dc.contributor.author	Fusar-Poli, L.
dc.contributor.author	Delespaul, P.
dc.contributor.author	Kenis, G.
dc.contributor.author	Luykx, J.J.
dc.contributor.author	Lin, B.D.
dc.contributor.author	Richards, A.L.
dc.contributor.author	Akdede, B.
dc.contributor.author	Binbay, T.
dc.contributor.author	Altınyazar, V.
dc.contributor.author	Yalınçetin, B.
dc.contributor.author	Gümüş-Akay, G.
dc.contributor.author	Cihan, B.
dc.contributor.author	Soygür, H.
dc.contributor.author	Ulaş, H.
dc.contributor.author	Cankurtaran, E.Ş.
dc.contributor.author	Kaymak, S.U.
dc.contributor.author	Mihaljevic, M.M.
dc.contributor.author	Andric-Petrovic, S.
dc.contributor.author	Mirjanic, T.
dc.contributor.author	Bernardo, Miguel
dc.contributor.author	Mezquida, Gisel
dc.contributor.author	Amoretti, Silvia
dc.contributor.author	Bobes, Julio
dc.contributor.author	Saiz, Pilar
dc.contributor.author	García-Portilla, Maria Paz
dc.contributor.author	Sanjuán Arias, Julio
dc.contributor.author	Aguilar, Eduardo J.
dc.contributor.author	Santos, Jose Luis
dc.contributor.author	Jiménez-López, Estela
dc.contributor.author	Arrojo, Manuel
dc.contributor.author	Carracedo, Angel
dc.contributor.author	López, Gonzalo
dc.contributor.author	González-Peñas, Javier
dc.contributor.author	Parellada, Mara
dc.contributor.author	Maric, N.P.
dc.contributor.author	Atbaşoğlu, C.
dc.contributor.author	Ucok, A.
dc.date.accessioned	2021-05-04T10:43:31Z
dc.date.available	2021-05-04T10:43:31Z
dc.date.issued	2021
dc.identifier.citation	Erzin, G. Pries, L.K. van Os, J. Fusar-Poli, L. Delespaul, P. Kenis, G. Luykx, J.J. Lin, B.D. Richards, A.L. Akdede, B. Binbay, T. Alt&#305nyazar, V. Yal&#305nçetin, B. Gümü&#351-Akay, G. Cihan, B. Soygür, H. Ula&#351, H. Cankurtaran, E.&#350. Kaymak, S.U. Mihaljevic, M.M. Andric-Petrovic, S. Mirjanic, T. Bernardo, Miguel Mezquida, Gisel Amoretti, Silvia Bobes, Julio Saiz, Pilar García-Portilla, Maria Paz Sanjuan Arias, Julio Aguilar, Eduardo J. Santos, Jose Luis Jiménez-López, Estela Arrojo, Manuel Carracedo, Angel López, Gonzalo González-Peñas, Javier Parellada, Mara Maric, N.P. Atba&#351o&#287lu, C. Ucok, A. 2021 Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study. European Psychiatry
dc.identifier.uri	https://hdl.handle.net/10550/79071
dc.description.abstract	Background. A cumulative environmental exposure score for schizophrenia (exposome score for schizophrenia [ES-SCZ]) may provide potential utility for risk stratification and outcome prediction. Here, we investigated whether ES-SCZ was associated with functioning in patients with schizophrenia spectrum disorder, unaffected siblings, and healthy controls. Methods. This cross-sectional sample consisted of 1,261 patients, 1,282 unaffected siblings, and 1,525 healthy controls. The Global Assessment of Functioning (GAF) scale was used to assess functioning. ES-SCZ was calculated based on our previously validated method. The association between ES-SCZ and the GAF dimensions (symptom and disability) was analyzed by applying regression models in each group (patients, siblings, and controls). Additional models included polygenic risk score for schizophrenia (PRS-SCZ) as a covariate. Results. ES-SCZ was associated with the GAF dimensions in patients (symptom: B = 1.53, p-value = 0.001; disability: B = 1.44, p-value = 0.001), siblings (symptom: B = 3.07, p-value < 0.001; disability: B = 2.52, p-value < 0.001), and healthy controls (symptom: B = 1.50, p-value < 0.001; disability: B = 1.31, p-value < 0.001). The results remained the same after adjusting for PRS-SCZ. The degree of associations of ES-SCZ with both symptom and disability dimensions were higher in unaffected siblings than in patients and controls. By analyzing an independent dataset (the Genetic Risk and Outcome of Psychosis study), we replicated the results observed in the patient group. Conclusions. Our findings suggest that ES-SCZ shows promise for enhancing risk prediction and stratification in research practice. From a clinical perspective, ES-SCZ may aid in efforts of clinical characterization, operationalizing transdiagnostic clinical staging models, and personalizing clinical management.
dc.language.iso	eng
dc.relation.ispartof	European Psychiatry, 2021
dc.subject	Psiquiatria
dc.title	Examining the association between exposome score for schizophrenia and functioning in schizophrenia, siblings, and healthy controls: Results from the EUGEI study.
dc.type	journal article	es_ES
dc.date.updated	2021-05-04T10:43:31Z
dc.identifier.doi	10.1192/j.eurpsy.2021.19
dc.identifier.idgrec	146670
dc.rights.accessRights	open access	es_ES