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Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas

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Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas

dc.contributor.author	Soares, Ciro Dantas	es
dc.contributor.author	Hernández Guerrero, Juan Carlos	es
dc.contributor.author	Andrade, Bruno Augusto Benevenuto de	es
dc.contributor.author	Romañach, Mário José	es
dc.contributor.author	Mosqueda Taylor, Adalberto	es
dc.contributor.author	Carlos, Román	es
dc.contributor.author	Macedo, Madja Ruanna Soares	es
dc.contributor.author	Almeida, Oslei Paes de	es
dc.contributor.author	Jorge, Jacks	es
dc.date.accessioned	2021-05-04T11:01:19Z
dc.date.available	2021-05-04T11:01:19Z
dc.date.issued	2020	es
dc.identifier.citation	Soares, Ciro Dantas ; Hernández Guerrero, Juan Carlos ; Andrade, Bruno Augusto Benevenuto de ; Romañach, Mário José ; Mosqueda Taylor, Adalberto ; Carlos, Román ; Macedo, Madja Ruanna Soares ; Almeida, Oslei Paes de ; Jorge, Jacks. Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas. En: Medicina oral, patología oral y cirugía bucal. Ed. inglesa, 25 6 2020: 15-	es
dc.identifier.uri	https://hdl.handle.net/10550/79089
dc.description.abstract	Oral melanomas have some histopathological resemblance with its cutaneous counterpart; however, an aggressive behavior is more common in tumors that occur in the oral cavity. Several markers have been suggested as indicative of tumoral progression and aggressiveness, such as cyclooxygenase 2 (COX-2) and Ki67. In this study, we have compared the expression of COX-2 and Ki67 in a series of amelanotic (n=7) and melanotic oral melanomas (n=22). The cases were selected from 4 pathology laboratories and submitted to the immunohistochemical (IHC) reactions. We analyzed the IHC staining based on a qualitative ? using visual scores; and a computer-assisted method (quantitative) using scanned slides and software for digital analysis. COX-2 was expressed in all oral melanomas; however, its intensity was significantly higher in the amelanotic ones (P<0.001). Similarly, a high Ki67-positivity index was observed in the amelanotic than melanotic ones (P<0.001). Based on these results, we suggest that amelanotic oral melanomas have marked pro-inflammatory and high-proliferative phenotype, justifying their more aggressive behavior compared with the melanotic ones.	es
dc.title	Comparative expression of cyclooxygenase 2 and Ki67 in amelanotic and conventional oral melanomas	es
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS MÉDICAS	es
dc.identifier.doi	10.4317/medoral.23737	es
dc.type.hasVersion	VoR	es_ES