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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

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First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm

dc.contributor.author	González Vivas, Carlos
dc.contributor.author	García Martí, Gracián
dc.contributor.author	Soldevila Matías, Pablo
dc.contributor.author	Sanz-Requena, Roberto
dc.contributor.author	Aguilar, Eduardo J.
dc.contributor.author	Castro Bleda, María José
dc.contributor.author	Martí Bonmatí, Luis
dc.contributor.author	Sanjuán Arias, Julio
dc.date.accessioned	2021-05-04T16:21:54Z
dc.date.available	2021-05-04T16:21:54Z
dc.date.issued	2020
dc.identifier.citation	González Vivas, Carlos García Martí, Gracián Soldevila Matías, Pablo Sanz-Requena, Roberto Aguilar, Eduardo J. Castro Bleda, María José Martí Bonmatí, Luis Sanjuán Arias, Julio 2020 First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm Frontiers In Psychiatry 11
dc.identifier.uri	https://hdl.handle.net/10550/79103
dc.description.abstract	Most previous longitudinal studies of functional magnetic resonance imaging (fMRI) in first-episode psychosis (FEP) using cognitive paradigm task found an increased activation after antipsychotic medications. We designed an emotional auditory paradigm to explore brain activation during emotional and nonemotional word processing. This study aimed to analyze if longitudinal changes in brain fMRI BOLD activation is present in patients vs. healthy controls. A group of FEP patients (n = 34) received clinical assessment and had a fMRI scan at baseline and follow-up (average, 25-month interval). During the fMRI scan, both emotional and nonemotional words were presented as a block design. Results were compared with a pair of healthy control group (n = 13). Patients showed a decreased activation at follow-up fMRI in amygdala (F = 4.69; p = 0.04) and hippocampus (F = 5.03; p = 0.03) compared with controls. Middle frontal gyrus was the only area that showed a substantial increased activation in patients (F = 4.53; p = 0.04). A great heterogeneity in individual activation patterns was also found. These results support the relevance of the type of paradigm in neuroimaging for psychosis. This is, as far as we know, the first longitudinal study with an emotional auditory paradigm in FEP. Our results suggested that the amygdala and hippocampus play a key role in psychotic disease. More studies are needed to understand the heterogeneity of response at individual level.
dc.language.iso	eng
dc.relation.ispartof	Frontiers In Psychiatry, 2020, vol. 11
dc.subject	Psiquiatria
dc.title	First-Episode Psychotic Patients Showed Longitudinal Brain Changes Using fMRI With an Emotional Auditory Paradigm
dc.type	journal article	es_ES
dc.date.updated	2021-05-04T16:21:55Z
dc.identifier.doi	10.3389/fpsyt.2020.593042
dc.identifier.idgrec	146672
dc.rights.accessRights	open access	es_ES