The phenomenon of entrepreneurship has driven much of the attention of academics, practitioners and policy makers. A correct and deep understanding of all the different conditions affecting entrepreneurship rates will advance in the establishment of useful measures that increase entrepreneurial success. The vast majority of the literature on the effect of institutional quality on entrepreneurship has been investigated based on average effects. However, how the impact of institutional quality on the level of entrepreneurship varies with the conditional distribution of entrepreneurship is still poorly understood. The present study attempts to fill the research gaps in this field. In order to examine the impact of institutional quality on entrepreneurship at different entrepreneurship levels, the fuzzy set qualitative comparative analysis approach is employed. Results show that entrepreneurial success is determined by the combination of the following conditions of institutional quality: voice accountability, political stability, regulatory quality and rule of law. Implications and future research directions are discussed. It would be interesting to analyze in future studies the motivation to become an entrepreneur, both theoretically and empirically, differentiating between opportunity and necessity entrepreneurship.