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Cyanocobalamin ultraflexible lipid vesicles: Characterization and in vitro evaluation of drug-skin depth profiles

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Cyanocobalamin ultraflexible lipid vesicles: Characterization and in vitro evaluation of drug-skin depth profiles

dc.contributor.author	Guillot García, Antonio José
dc.contributor.author	Jornet-Mollá, Enrique
dc.contributor.author	Landsberg, Natalia
dc.contributor.author	Milián-Guimerá, Carmen
dc.contributor.author	Montesinos Mezquita, María Carmen
dc.contributor.author	Garrigues Pelufo, Teresa María
dc.contributor.author	Melero Zaera, Ana
dc.date.accessioned	2021-07-26T12:51:21Z
dc.date.available	2021-07-26T12:51:21Z
dc.date.issued	2021
dc.identifier.citation	Guillot García, Antonio José Jornet-Mollá, Enrique Landsberg, Natalia Milián-Guimerá, Carmen Montesinos Mezquita, Mª Carmen Garrigues Pelufo, Teresa María Melero Zaera, Ana 2021 Cyanocobalamin ultraflexible lipid vesicles: Characterization and in vitro evaluation of drug-skin depth profiles Pharmaceutics 13 3 418
dc.identifier.uri	https://hdl.handle.net/10550/80036
dc.description.abstract	Atopic dermatitis (AD) and psoriasis are the most common chronic inflammatory skin disorders, which importantly affect the quality of life of patients who suffer them. Among other causes, nitric oxide has been reported as part of the triggering factors in the pathogenesis of both conditions. Cyanocobalamin (vitamin B12) has shown efficacy as a nitric oxide scavenger and some clinical trials have given positive outcomes in its use for treating skin pathologies. Passive skin diffusion is possible only for drugs with low molecular weights and intermediate lipophilicity. Unfortunately, the molecular weight and hydrophilicity of vitamin B12 do not predict its effective diffusion through the skin. The aim of this work was to design new lipid vesicles to encapsulate the vitamin B12 to enhance its skin penetration. Nine prototypes of vesicles were generated and characterized in terms of size, polydispersity, surface charge, drug encapsulation, flexibility, and stability with positive results. Additionally, their ability to release the drug content in a controlled manner was demonstrated. Finally, we found that these lipid vesicle formulations facilitated the penetration of cyanocobalamin to the deeper layers of the skin. The present work shows a promising system to effectively administer vitamin B12 topically, which could be of interest in the treatment of skin diseases such as AD and psoriasis.
dc.language.iso	eng
dc.relation.ispartof	Pharmaceutics, 2021, vol. 13, num. 3, p. 418
dc.subject	Dermatitis
dc.subject	Pell
dc.subject	Tecnologia farmacèutica
dc.title	Cyanocobalamin ultraflexible lipid vesicles: Characterization and in vitro evaluation of drug-skin depth profiles
dc.type	journal article	es_ES
dc.date.updated	2021-07-26T12:51:22Z
dc.identifier.doi	10.3390/pharmaceutics13030418
dc.identifier.idgrec	146943
dc.rights.accessRights	open access	es_ES