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Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

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Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study

dc.contributor.author	Misra, Supriya
dc.contributor.author	Gelaye, Bizu
dc.contributor.author	Koenen, Karestan C.
dc.contributor.author	Williams, David R.
dc.contributor.author	Borba, Christina
dc.contributor.author	Quattrone, Diego
dc.contributor.author	Di Forti, Marta
dc.contributor.author	La Cascia, Caterina
dc.contributor.author	La Barbera, Daniele
dc.contributor.author	Tarricone, Ilaria
dc.contributor.author	Berardi, Domenico
dc.contributor.author	Szoke, Andrei
dc.contributor.author	Arango, Celso
dc.contributor.author	Tortelli, Andrea
dc.contributor.author	De Haan, Lieuwe
dc.contributor.author	Velthorst, Eva
dc.contributor.author	Bobes, Julio
dc.contributor.author	Bernardo, Miguel
dc.contributor.author	Sanjuán Arias, Julio
dc.contributor.author	Santos, Jose Luis
dc.contributor.author	Arrojo, Manuel
dc.contributor.author	Del‑Ben, Cristina Marta
dc.contributor.author	Menezes, Paulo Rossi
dc.contributor.author	Selten, Jean-Paul
dc.contributor.author	Jones, Peter B.
dc.contributor.author	Kirkbride, James B.
dc.contributor.author	Rutten, Bart P.F.
dc.contributor.author	van Os, J.
dc.contributor.author	Murray, Robin
dc.contributor.author	Gayer-Anderson, Charlotte
dc.contributor.author	Morgan, Craig
dc.date.accessioned	2021-07-27T17:04:03Z
dc.date.available	2021-07-27T17:04:03Z
dc.date.issued	2019
dc.identifier.citation	Misra, Supriya Gelaye, Bizu Koenen, Karestan C. Williams, David R. Borba, Christina Quattrone, Diego Di Forti, Marta La Cascia, Caterina La Barbera, Daniele Tarricone, Ilaria Berardi, Domenico Szoke, Andrei Arango, Celso Tortelli, Andrea De Haan, Lieuwe Velthorst, Eva Bobes, Julio Bernardo, Miguel Sanjuán Arias, Julio Santos, Jose Luis Arrojo, Manuel Del&#8209Ben, Cristina Marta Menezes, Paulo Rossi Selten, Jean-Paul Jones, Peter B. Kirkbride, James B. Rutten, Bart P.F. van Os, J. Murray, Robin Gayer-Anderson, Charlotte Morgan, Craig 2019 Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study Journal Of Clinical Medicine 8 7 1081
dc.identifier.uri	https://hdl.handle.net/10550/80047
dc.description.abstract	Evidence for early parental death as a risk factor for psychosis in offspring is inconclusive. We analyzed data from a six-country, case-control study to examine the associations of early parental death, type of death (maternal, paternal, both), and child's age at death with psychosis, both overall and by ethnic group. In fully adjusted multivariable mixed-effects logistic regression models, experiencing early parental death was associated with 1.54-fold greater odds of psychosis (95% confidence interval (CI): 1.23, 1.92). Experiencing maternal death had 2.27-fold greater odds (95% CI: 1.18, 4.37), paternal death had 1.14-fold greater odds (95% CI: 0.79, 1.64), and both deaths had 4.42-fold greater odds (95% CI: 2.57, 7.60) of psychosis compared with no early parental death. Experiencing parental death between 11 and 16 years of age had 2.03-fold greater odds of psychosis than experiencing it before five years of age (95% CI: 1.02, 4.04). In stratified analyses, experiencing the death of both parents had 9.22-fold greater odds of psychosis among minority ethnic groups (95% CI: 2.02-28.02) and no elevated odds among the ethnic majority (odds ratio (OR): 0.96; 95% CI: 0.10-8.97), which could be due in part to the higher prevalence of early parental death among minority ethnic groups but should be interpreted cautiously given the wide confidence intervals.
dc.relation.ispartof	Journal Of Clinical Medicine, 2019, vol. 8, num. 7, p. 1081
dc.subject	Psiquiatria
dc.subject	Infants Salut mental
dc.subject	Esquizofrènia
dc.title	Early Parental Death and Risk of Psychosis in Offspring: A Six-Country Case-Control Study
dc.type	journal article	es_ES
dc.date.updated	2021-07-27T17:04:03Z
dc.identifier.doi	10.3390/jcm8071081
dc.identifier.idgrec	145589
dc.rights.accessRights	open access	es_ES