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White noise speech illusions: A trait-dependent risk marker for psychotic disorder?

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White noise speech illusions: A trait-dependent risk marker for psychotic disorder?

dc.contributor.author	Schepers, Elaine
dc.contributor.author	Lousberg, Richel
dc.contributor.author	Guloksuz, Sinan
dc.contributor.author	Pries, L.K.
dc.contributor.author	Delespaul, P.
dc.contributor.author	Kenis, Gunter
dc.contributor.author	Luykx, J.J.
dc.contributor.author	Lin, B.D.
dc.contributor.author	Richards, A.L.
dc.contributor.author	Akdede, B.
dc.contributor.author	Binbay, T.
dc.contributor.author	Altınyazar, V.
dc.contributor.author	Yalınçetin, B.
dc.contributor.author	Gümüş-Akay, G.
dc.contributor.author	Cihan, B.
dc.contributor.author	Soygür, H.
dc.contributor.author	Ulaş, H.
dc.contributor.author	Şahin Cankurtaranm, E.
dc.contributor.author	Ulusoy Kaymak, S.
dc.contributor.author	Mihaljevic, M.M.
dc.contributor.author	Andric-Petrovic, S.
dc.contributor.author	Mirjanic, T.
dc.contributor.author	Bernardo, Miguel
dc.contributor.author	Cabrera, Bibiana
dc.contributor.author	Bobes, Julio
dc.contributor.author	Saiz, Pilar
dc.contributor.author	García-Portilla, Maria Paz
dc.contributor.author	Sanjuán Arias, Julio
dc.contributor.author	Aguilar, Eduardo J.
dc.contributor.author	Santos, Jose Luis
dc.contributor.author	Jiménez-López, Estela
dc.contributor.author	Arrojo, Manuel
dc.contributor.author	Carracedo, Angel
dc.contributor.author	López, Gonzalo
dc.contributor.author	González-Peñas, Javier
dc.contributor.author	Parellada, Mara
dc.contributor.author	Maric, N.P.
dc.contributor.author	Atbaşoğlu, C.
dc.contributor.author	Ucok, A.
dc.contributor.author	Alptekin, Koksal
dc.date.accessioned	2021-07-30T14:42:17Z
dc.date.available	2021-07-30T14:42:17Z
dc.date.issued	2019
dc.identifier.citation	Schepers, Elaine Lousberg, Richel Guloksuz, Sinan Pries, L.K. Delespaul, P. Kenis, Gunter Luykx, J.J. Lin, B.D. Richards, A.L. Akdede, B. Binbay, T. Alt&#305nyazar, V. Yal&#305nçetin, B. Gümü&#351-Akay, G. Cihan, B. Soygür, H. Ula&#351, H. &#350ahin Cankurtaranm, E. Ulusoy Kaymak, S. Mihaljevic, M.M. Andric-Petrovic, S. Mirjanic, T. Bernardo, Miguel Cabrera, Bibiana Bobes, Julio Saiz, Pilar García-Portilla, Maria Paz Sanjuán Arias, Julio Aguilar, Eduardo J. Santos, Jose Luis Jiménez-López, Estela Arrojo, Manuel Carracedo, Angel López, Gonzalo González-Peñas, Javier Parellada, Mara Maric, N.P. Atba&#351o&#287lu, C. Ucok, A. Alptekin, Koksal 2019 White noise speech illusions: A trait-dependent risk marker for psychotic disorder? Frontiers In Psychiatry 10 676
dc.identifier.uri	https://hdl.handle.net/10550/80095
dc.description.abstract	Introduction: White noise speech illusions index liability for psychotic disorder in case-control comparisons. In the current study, we examined i) the rate of white noise speech illusions in siblings of patients with psychotic disorder and ii) to what degree this rate would be contingent on exposure to known environmental risk factors (childhood adversity and recent life events) and level of known endophenotypic dimensions of psychotic disorder [psychotic experiences assessed with the Community Assessment of Psychic Experiences (CAPE) scale and cognitive ability]. Methods: The white noise task was used as an experimental paradigm to elicit and measure speech illusions in 1,014 patients with psychotic disorders, 1,157 siblings, and 1,507 healthy participants. We examined associations between speech illusions and increasing familial risk (control -> sibling -> patient), modeled as both a linear and a categorical effect, and associations between speech illusions and level of childhood adversities and life events as well as with CAPE scores and cognitive ability scores. Results: While a positive association was found between white noise speech illusions across hypothesized increasing levels of familial risk (controls -> siblings -> patients) [odds ratio (OR) linear 1.11, 95% confidence interval (CI) 1.02-1.21, p = 0.019], there was no evidence for a categorical association with sibling status (OR 0.93, 95% CI 0.79-1.09, p = 0.360). The association between speech illusions and linear familial risk was greater if scores on the CAPE positive scale were higher (p interaction = 0.003; ORlow CAPE positive scale 0.96, 95% CI 0.85-1.07; ORhigh CAPE positive scale 1.26, 95% CI 1.09-1.46); cognitive ability was lower (p interaction < 0.001; ORhigh cognitive ability 0.94, 95% CI 0.84-1.05; ORlow cognitive ability 1.43, 95% CI 1.23-1.68); and exposure to childhood adversity was higher (p interaction < 0.001; ORlow adversity 0.92, 95% CI 0.82-1.04; ORhigh adversity 1.31, 95% CI 1.13-1.52). A similar, although less marked, pattern was seen for categorical patient-control and sibling-control comparisons. Exposure to recent life events did not modify the association between white noise and familial risk (p interaction = 0.232). Conclusion: The association between white noise speech illusions and familial risk is contingent on additional evidence of endophenotypic expression and of exposure to childhood adversity. Therefore, speech illusions may represent a trait-dependent risk marker.
dc.language.iso	spa
dc.relation.ispartof	Frontiers In Psychiatry, 2019, vol. 10, p. 676
dc.subject	Salut mental
dc.subject	Psiquiatria
dc.subject	Trastorns de la parla
dc.title	White noise speech illusions: A trait-dependent risk marker for psychotic disorder?
dc.type	journal article	es_ES
dc.date.updated	2021-07-30T14:42:18Z
dc.identifier.doi	10.3389/fpsyt.2019.00676
dc.identifier.idgrec	135049
dc.rights.accessRights	open access	es_ES