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The evolution and changing ecology of the African hominid oral microbiome

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The evolution and changing ecology of the African hominid oral microbiome

dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Velsko I.M.
dc.contributor.author	Aron F.
dc.contributor.author	Posth C.
dc.contributor.author	Hofmam C.A.
dc.contributor.author	Austin R.M.
dc.contributor.author	Parker C.E.
dc.contributor.author	Mann A.E.
dc.contributor.author	Nägale K.
dc.contributor.author	Weedman Arthur K.
dc.contributor.author	Arthur J.W.
dc.contributor.author	Bauer C.C.
dc.contributor.author	Crevecoeur I.
dc.contributor.author	Cupillard C.
dc.contributor.author	Curtis M.C.
dc.contributor.author	Dalén L.
dc.contributor.author	Díaz-Zorita Bonilla M.
dc.contributor.author	Díez Fernández Lomana J.C.
dc.contributor.author	Drucker D.G.
dc.contributor.author	Escribano Escrivá E.
dc.contributor.author	Francken M.
dc.contributor.author	Gibbon V.E.
dc.contributor.author	González Morales M.R.
dc.contributor.author	Grande Mateu A.
dc.contributor.author	Harvati K.
dc.contributor.author	Henry A.G.
dc.contributor.author	Humphrey L.
dc.contributor.author	Menéndez M.
dc.contributor.author	Mihailovic D.
dc.contributor.author	Peresani M.
dc.contributor.author	Rodríguez Moroder S.
dc.contributor.author	Roksandic M.
dc.contributor.author	Rougier H.
dc.contributor.author	Sázelová S.
dc.contributor.author	Stock J.T.
dc.contributor.author	Guy Strauss L.
dc.contributor.author	Svooboda J.
dc.contributor.author	Tessmann B.
dc.contributor.author	Walker M.J.
dc.contributor.author	Power R.C.
dc.date.accessioned	2021-09-01T07:56:13Z
dc.date.available	2021-09-01T07:56:13Z
dc.date.issued	2021
dc.identifier.citation	Salazar García, Domingo Carlos Velsko I.M. Aron F. Posth C. Hofmam C.A. Austin R.M. Parker C.E. Mann A.E. Nägale K. Weedman Arthur K. Arthur J.W. Bauer C.C. Crevecoeur I. Cupillard C. Curtis M.C. Dalén L. Díaz-Zorita Bonilla M. Díez Fernández Lomana J.C. Drucker D.G. Escribano Escrivá E. Francken M. Gibbon V.E. González Morales M.R. Grande Mateu A. Harvati K. Henry A.G. Humphrey L. Menéndez M. Mihailovic D. Peresani M. Rodríguez Moroder S. Roksandic M. Rougier H. Sázelová S. Stock J.T. Guy Strauss L. Svooboda J. Tessmann B. Walker M.J. Power R.C. 2021 The evolution and changing ecology of the African hominid oral microbiome Proceedings of the National Academy of Sciences of the United States of America 118 20 e2021655118
dc.identifier.uri	https://hdl.handle.net/10550/80147
dc.description.abstract	The oral microbiome plays key roles in human biology, health, and disease, but little is known about the global diversity, variation, or evolution of this microbial community. To better understand the evolution and changing ecology of the human oral microbiome, we analyzed 124 dental biofilm metagenomes from humans, including Neanderthals and Late Pleistocene to present-day modern humans, chimpanzees, and gorillas, as well as New World howler monkeys for comparison. We find that a core microbiome of primarily biofilm structural taxa has been maintained throughout African hominid evolution, and these microbial groups are also shared with howler monkeys, suggesting that they have been important oral members since before the catarrhine-platyrrhine split ca. 40 Mya. However, community structure and individual microbial phylogenies do not closely reflect host relationships, and the dental biofilms of Homo and chimpanzees are distinguished by major taxonomic and functional differences. Reconstructing oral metagenomes from up to 100 thousand years ago, we show that the microbial profiles of both Neanderthals and modern humans are highly similar, sharing functional adaptations in nutrient metabolism. These include an apparent Homo-specific acquisition of salivary amylase-binding capability by oral streptococci, suggesting microbial coadaptation with host diet. We additionally find evidence of shared genetic diversity in the oral bacteria of Neanderthal and Upper Paleolithic modern humans that is not observed in later modern human populations. Differences in the oral microbiomes of African hominids provide insights into human evolution, the ancestral state of the human microbiome, and a temporal framework for understanding microbial health and disease.
dc.language.iso	eng
dc.relation.ispartof	Proceedings of the National Academy of Sciences of the United States of America, 2021, vol. 118, num. 20, p. e2021655118
dc.subject	Prehistòria
dc.title	The evolution and changing ecology of the African hominid oral microbiome
dc.type	journal article	es_ES
dc.date.updated	2021-09-01T07:56:13Z
dc.identifier.doi	10.1073/pnas.2021655118
dc.identifier.idgrec	147550
dc.rights.accessRights	open access	es_ES