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Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidencefor a two-path Neolithic expansion to Western Europe

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Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidencefor a two-path Neolithic expansion to Western Europe

dc.contributor.author	Rohrlach A.B.
dc.contributor.author	Papac L.
dc.contributor.author	Childebayeva A.
dc.contributor.author	Rivollat M.
dc.contributor.author	Villalba-Mouco V.
dc.contributor.author	Neumann G.U.
dc.contributor.author	Penske S.
dc.contributor.author	Skourtanioti E.
dc.contributor.author	van der Loosdrecht M.
dc.contributor.author	Akar M.
dc.contributor.author	Boyadzhiev K.
dc.contributor.author	Boyadzhuev Y.
dc.contributor.author	Deguilloux M.F.
dc.contributor.author	Dobes M.
dc.contributor.author	Erdal Y.S.
dc.contributor.author	Ernée M.
dc.contributor.author	Frangipane M.
dc.contributor.author	Furmanek M.
dc.contributor.author	Friederich S.
dc.contributor.author	Ghesquière E.
dc.contributor.author	Hakluszko A.
dc.contributor.author	Hansen S.
dc.contributor.author	Küssner M.
dc.contributor.author	Mannino M.
dc.contributor.author	Özbal R.
dc.contributor.author	Reinhgold S.
dc.contributor.author	Rottier S.
dc.contributor.author	Salazar García, Domingo Carlos
dc.contributor.author	Soler Diaz J.
dc.contributor.author	Stockhammer P.W.
dc.contributor.author	Roca de Togores Muñoz C.
dc.contributor.author	Aslihan Yener K.
dc.contributor.author	Posth C.
dc.contributor.author	Krause J.
dc.contributor.author	Herbig A.
dc.contributor.author	Haak W.
dc.date.accessioned	2021-09-01T09:08:17Z
dc.date.available	2021-09-01T09:08:17Z
dc.date.issued	2021
dc.identifier.citation	Rohrlach A.B. Papac L. Childebayeva A. Rivollat M. Villalba-Mouco V. Neumann G.U. Penske S. Skourtanioti E. van der Loosdrecht M. Akar M. Boyadzhiev K. Boyadzhuev Y. Deguilloux M.F. Dobes M. Erdal Y.S. Ernée M. Frangipane M. Furmanek M. Friederich S. Ghesquière E. Hakluszko A. Hansen S. Küssner M. Mannino M. Özbal R. Reinhgold S. Rottier S. Salazar García, Domingo Carlos Soler Diaz J. Stockhammer P.W. Roca de Togores Muñoz C. Aslihan Yener K. Posth C. Krause J. Herbig A. Haak W. 2021 Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidencefor a two-path Neolithic expansion to Western Europe Scientific Reports 11:15005
dc.identifier.uri	https://hdl.handle.net/10550/80158
dc.description.abstract	Uniparentally-inherited markers on mitochondrial DNA (mtDNA) and the non-recombining regions of the Y chromosome (NRY), have been used for the past 30 years to investigate the history of humans from a maternal and paternal perspective. Researchers have preferred mtDNA due to its abundance in the cells, and comparatively high substitution rate. Conversely, the NRY is less susceptible to back mutations and saturation, and is potentially more informative than mtDNA owing to its longer sequence length. However, due to comparatively poor NRY coverage via shotgun sequencing, and the relatively low and biased representation of Y-chromosome variants on capture assays such as the 1240 k, ancient DNA studies often fail to utilize the unique perspective that the NRY can yield. Here we introduce a new DNA enrichment assay, coined YMCA (Y-mappable capture assay), that targets the 'mappable' regions of the NRY. We show that compared to low-coverage shotgun sequencing and 1240 k capture, YMCA significantly improves the mean coverage and number of sites covered on the NRY, increasing the number of Y-haplogroup informative SNPs, and allowing for the identification of previously undiscovered variants. To illustrate the power of YMCA, we show that the analysis of ancient Y-chromosome lineages can help to resolve Y-chromosomal haplogroups. As a case study, we focus on H2, a haplogroup associated with a critical event in European human history: the Neolithic transition. By disentangling the evolutionary history of this haplogroup, we further elucidate the two separate paths by which early farmers expanded from Anatolia and the Near East to western Europe.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2021, num. 11:15005
dc.subject	Prehistòria
dc.title	Using Y-chromosome capture enrichment to resolve haplogroup H2 shows new evidencefor a two-path Neolithic expansion to Western Europe
dc.type	journal article	es_ES
dc.date.updated	2021-09-01T09:08:18Z
dc.identifier.doi	10.1038/s41598-021-94491-z
dc.identifier.idgrec	147553
dc.rights.accessRights	open access	es_ES