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Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women
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Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women
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| dc.contributor.author | Novella, Susana | |
| dc.contributor.author | Pérez-Cremades, Daniel | |
| dc.contributor.author | Mompeón, Ana | |
| dc.contributor.author | Hermenegildo, Carlos | |
| dc.date.accessioned | 2021-09-13T12:06:57Z | |
| dc.date.available | 2021-09-13T12:06:57Z | |
| dc.date.issued | 2019 | |
| dc.identifier.citation | Novella S Pérez-Cremades D Mompeón A Hermenegildo, Carlos 2019 Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women Journal of Physiology-London 597 4873 4886 | |
| dc.identifier.uri | https://hdl.handle.net/10550/80296 | |
| dc.description.abstract | Women show a lower incidence of cardiovascular diseases than aged-matched men, but this benefit disappears after menopause. Oestrogen-mediated vascular actions are mainly attributed to oestradiol and exerted by oestrogen receptors (ERα, ERβ, and GPER), through rapid and/or genomic mechanisms, but these effects depend on ageing and inflammation. A cardiovascular approach in women's health has arisen due to controversy regarding oestrogens' beneficial impact as reported in experimental and observational studies and large randomized trials. These can be explained, in part, by two mutually non-exclusive hypotheses. On the one hand, the timing hypothesis, which states that oestrogen-mediated benefits occur before the detrimental effects of ageing are established in the vasculature; on the other hand, ageing and/or hormonal-associated changes in ER expression that could lead to a deleterious imbalance in favour of ERβ over ERα, generally associated with higher inflammation and endothelial dysfunction. In experimental studies, oestradiol acting on ERα promotes the release of vasoactive compounds such as nitric oxide (NO) and prostacyclin, and shifts the angiotensin axis towards angiotensin 1-7 production. Mechanisms underlying oestradiol vascular function also include anti-inflammatory and epigenetic modifications. 17β-oestradiol changes the transcriptomic profile of endothelial cells, and the involvement of miRNA in the regulatory pathways of vascular function reinforces assumptions regarding the vascular actions of oestrogen. Thus, the present symposium review aims to postulate the role of ERα in oestrogen modulation of endothelial-derived mediators and vascular physiology, as well as its relationship with miRNA and inflammation, and elucidate how physiological changes in postmenopausal women counteract the observed effects. | |
| dc.language.iso | eng | |
| dc.relation.ispartof | Journal of Physiology-London, 2019, vol. 597, p. 4873-4886 | |
| dc.subject | Medicina | |
| dc.title | Mechanisms underlying the influence of oestrogen on cardiovascular physiology in women | |
| dc.type | journal article | es_ES |
| dc.date.updated | 2021-09-13T12:06:57Z | |
| dc.identifier.doi | 10.1113/JP278063 | |
| dc.identifier.idgrec | 136983 | |
| dc.rights.accessRights | open access | es_ES |
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