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Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota

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Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota

dc.contributor.author	Rubio-Del-Campo, Antonio
dc.contributor.author	Alcántara, Cristina
dc.contributor.author	Collado, María Carmen
dc.contributor.author	Rodríguez Díaz, Jesús
dc.contributor.author	Yebra Yebra, María Jesús
dc.date.accessioned	2021-10-13T13:31:31Z
dc.date.available	2021-10-13T13:31:31Z
dc.date.issued	2020
dc.identifier.citation	Rubio-Del-Campo, Antonio Alcántara, Cristina Collado, María Carmen Rodríguez Díaz, Jesús Yebra Yebra, María Jesús 2020 Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota Scientific Reports 10 11845 1 12
dc.identifier.uri	https://hdl.handle.net/10550/80457
dc.description.abstract	Human milk oligosaccharides (HMOs) are a mixture of structurally diverse carbohydrates that contribute to shape a healthy gut microbiota composition. The great diversity of the HMOs structures does not allow the attribution of specific prebiotic characteristics to single milk oligosaccharides. We analyze here the utilization of four disaccharides, lacto-N-biose (LNB), galacto-N-biose (GNB), fucosyl-alpha 1,3-GlcNAc (3FN) and fucosyl-alpha 1,6-GlcNAc (6FN), that form part of HMOs and glycoprotein structures, by the infant fecal microbiota. LNB significantly increased the total levels of bifidobacteria and the species Bifidobacterium breve and Bifidobacterium bifidum. The Lactobacillus genus levels were increased by 3FN fermentation and B. breve by GNB and 3FN. There was a significant reduction of Blautia coccoides group with LNB and 3FN. In addition, 6FN significantly reduced the levels of Enterobacteriaceae family members. Significantly higher concentrations of lactate, formate and acetate were produced in cultures containing either LNB or GNB in comparison with control cultures. Additionally, after fermentation of the oligosaccharides by the fecal microbiota, several Bifidobacterium strains were isolated and identified. The results presented here indicated that each, LNB, GNB and 3FN disaccharide, might have a specific beneficial effect in the infant gut microbiota and they are potential prebiotics for application in infant foods.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2020, vol. 10, num. 11845, p. 1-12
dc.subject	Microbiologia
dc.subject	Lactobacils
dc.title	Human milk and mucosa-associated disaccharides impact on cultured infant fecal microbiota
dc.type	journal article	es_ES
dc.date.updated	2021-10-13T13:31:32Z
dc.identifier.doi	10.1038/s41598-020-68718-4
dc.identifier.idgrec	148217
dc.rights.accessRights	open access	es_ES