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The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol

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The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol

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dc.contributor.author	Fernández Rodríguez, Sandra
dc.contributor.author	Esposito-Zapero, Claudia
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Granero Maciá, Luis
dc.contributor.author	Cano Cebrián, María José
dc.date.accessioned	2021-10-15T13:30:02Z
dc.date.available	2021-10-15T13:30:02Z
dc.date.issued	2021
dc.identifier.citation	Fernández Rodríguez, Sandra Esposito-Zapero, Claudia Zornoza Sabina, Teodoro Polache Vengut, Ana Granero Maciá, Luis Cano Cebrián, María José 2021 The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol Pharmaceuticals 14(6) 593 1 12
dc.identifier.uri	https://hdl.handle.net/10550/80478
dc.description.abstract	N-acetylcysteine (NAC) is a prodrug that is marketed as a mucolytic agent and used for the treatment of acetaminophen overdose. Over the last few decades, evidence has been gathered that suggests the potential use of NAC as a new pharmacotherapy for alcohol use disorder (AUD), although its mechanism of action is already being debated. In this paper, we set out to assess both the potential involvement of the glutamate metabotropic receptors (mGluR) in the possible dual effect of NAC administered at two different doses and NAC's effect on ethanol-induced activation. To this aim, 30 or 120 mg/kg of NAC was intraperitoneally administered to rats with the presence or absence of the negative allosteric modulator of mGluR5 (MTEP 0.1 mg/kg). Thereafter, the cFOS IR-cell expression was analyzed. Secondly, we explored the effect of 120 mg/kg of NAC on the neurochemical and behavioral activation induced by intra-VTA ethanol administration (150 nmol). Our results showed that the high NAC dose stimulated cFOS expression in the NAcc, and that this effect was suppressed in the presence of MTEP, thus suggesting the implication of mGluR5. Additionally, high doses could attenuate the ethanol-induced increase in cFOS-expression in the NAcc, probably due to a phenomenon based on the long-term depression of the MSNs. Additional experiments are required to corroborate our hypothesis.
dc.language.iso	eng
dc.relation.ispartof	Pharmaceuticals, 2021, vol. 14(6), num. 593, p. 1-12
dc.subject	Alcoholisme
dc.subject	Tecnologia farmacèutica
dc.subject	Medicaments
dc.title	The Effects of N-Acetylcysteine on the Rat Mesocorticolimbic Pathway: Role of mGluR5 Receptors and Interaction with Ethanol
dc.type	journal article	es_ES
dc.date.updated	2021-10-15T13:30:02Z
dc.identifier.doi	10.3390/ph14060593
dc.identifier.idgrec	148261
dc.rights.accessRights	open access	es_ES