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Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay

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Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay

dc.contributor.author	Allaw, Mohamad
dc.contributor.author	Manconi, Maria
dc.contributor.author	Caboni, Pierluigi
dc.contributor.author	Bacchetta, Gianluigi
dc.contributor.author	Escribano-Ferrer, Elvira
dc.contributor.author	Peris Ribera, José Esteban
dc.contributor.author	Nácher Alonso, Amparo
dc.contributor.author	Díez Sales, Octavio
dc.contributor.author	Manca, Maria Letizia
dc.date.accessioned	2021-10-29T13:43:57Z
dc.date.available	2021-10-29T13:43:57Z
dc.date.issued	2021
dc.identifier.citation	Allaw, Mohamad Manconi, Maria Caboni, Pierluigi Bacchetta, Gianluigi Escribano-Ferrer, Elvira Peris Ribera, José Esteban Nácher Alonso, Amparo Díez Sales, Octavio Manca, Maria Letizia 2021 Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay Biomedicine & Pharmacotherapy 144 112351
dc.identifier.uri	https://hdl.handle.net/10550/80613
dc.description.abstract	Pistacia lentiscus L. is a sclerophyllous shrub capable of growing under harsh climatic conditions especially in the Mediterranean Basin. Different products can be obtained from this plant, such as essential oil, mastic gum or even fixed oil. The last is well known for its flavor which is mainly exploited in the food industry. Additionally, it has been traditionally used in the treatment of skin diseases, but, at the moment, any suitable formulation for skin delivery has been formulated and its biological effects was not deeply confirmed. Given that, in the present study, the lentisk oil has been formulated in liposomes at different concentrations (10, 20, 30 mg/ml) and their physicochemical, technological and main biological properties have been evaluated. Vesicles were prepared by using natural soy lecithin and a green and organic solvent free method, thus obtaining spherical, small (~ 118 nm), homogeneously dispersed (0.27) and highly negatively charged (~ -62 mV) vesicles. The used amount of oil loaded in liposomes (10, 20, 30 mg/ml) modulated the penetration ability of vesicles in the skin, favoring the deposition of the payload in the deeper strata. The loading in the vesicles potentiated the ability of oil to counteract the damaging effects caused by hydrogen peroxide in keratinocytes and fibroblasts and facilitate their migration in a cell monolayer lesion. Overall findings suggested that the incorporation of lentisk oil in liposomes made from soy lecithin can be an alternative and natural approach to exploit it in pharmaceutical ad cosmetical applications and manufacturing natural products suitable for the treatment of skin lesions.
dc.language.iso	eng
dc.relation.ispartof	Biomedicine & Pharmacotherapy, 2021, vol. 144, num. 112351
dc.subject	Farmacologia
dc.subject	Pell
dc.title	Formulation of liposomes loading lentisk oil to ameliorate topical delivery, attenuate oxidative stress damage and improve cell migration in scratch assay
dc.type	journal article	es_ES
dc.date.updated	2021-10-29T13:43:58Z
dc.identifier.doi	10.1016/j.biopha.2021.112351
dc.identifier.idgrec	148637
dc.rights.accessRights	open access	es_ES