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MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice

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MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice

dc.contributor.author	Abellán-Álvaro, María
dc.contributor.author	Stork, Oliver
dc.contributor.author	Agustín-Pavón, Carmen
dc.contributor.author	Santos, Mónica
dc.date.accessioned	2021-12-17T14:07:03Z
dc.date.available	2021-12-17T14:07:03Z
dc.date.issued	2021
dc.identifier.citation	Abellán-Álvaro, María Stork, Oliver Agustín-Pavón, Carmen Santos, Mónica 2021 MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice Journal of Neurodevelopmental Disorders 13 59 1 12
dc.identifier.uri	https://hdl.handle.net/10550/81087
dc.description.abstract	Background: Early-life stress can leave persistent epigenetic marks that may modulate vulnerability to psychiatric conditions later in life, including anxiety, depression and stress-related disorders. These are complex disorders with both environmental and genetic influences contributing to their etiology. Methyl-CpG Binding Protein 2 (MeCP2) has been attributed a key role in the control of neuronal activity-dependent gene expression and is a master regulator of experience-dependent epigenetic programming. Moreover, mutations in the MECP2 gene are the primary cause of Rett syndrome and, to a lesser extent, of a range of other major neurodevelopmental disorders. Here, we aim to study the interaction of MeCP2 with early-life stress in variables known to be affected by this environmental manipulation, namely anxiety-like behavior and activity of the underlying neural circuits. Methods: Using Mecp2 heterozygous and wild-type female mice we investigated the effects of the interaction of Mecp2 haplodeficiency with maternal separation later in life, by assessing anxiety-related behaviors and measuring concomitant c-FOS expression in stress- and anxiety-related brain regions of adolescent females. Moreover, arginine vasopressin and corticotropin-releasing hormone neurons of the paraventricular hypothalamic nucleus were analyzed for neuronal activation. Results: In wild-type mice, maternal separation caused a reduction in anxiety-like behavior and in the activation of the hypothalamic paraventricular nucleus, specifically in corticotropin-releasing hormone-positive cells, after the elevated plus maze. This effect of maternal separation was not observed in Mecp2 heterozygous females that per se show decreased anxiety-like behavior and concomitant decreased paraventricular nuclei activation.
dc.language.iso	eng
dc.relation.ispartof	Journal of Neurodevelopmental Disorders, 2021, vol. 13, num. 59, p. 1-12
dc.subject	Neurociències
dc.subject	Biologia
dc.title	MeCP2 haplodeficiency and early-life stress interaction on anxiety-like behavior in adolescent female mice
dc.type	journal article	es_ES
dc.date.updated	2021-12-17T14:07:04Z
dc.identifier.doi	10.1186/s11689-021-09409-7
dc.identifier.idgrec	149367
dc.rights.accessRights	open access	es_ES