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An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis

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An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis

dc.contributor.author	López-Blanch, Rafael
dc.contributor.author	Salvador Palmer, M. del Rosario
dc.contributor.author	Estrela Arigüel, José María
dc.contributor.author	Obrador, Elena
dc.date.accessioned	2021-12-20T17:19:03Z
dc.date.available	2021-12-20T17:19:03Z
dc.date.issued	2021
dc.identifier.citation	López-Blanch, Rafael Salvador Palmer, M. del Rosario Estrela Arigüel, José María Obrador, Elena 2021 An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis Antioxidants 10 2007
dc.identifier.uri	https://hdl.handle.net/10550/81101
dc.description.abstract	Oxidative stress has been proposed as a major mechanism of damage to motor neurons associated with the progression of amyotrophic lateral sclerosis (ALS). Astrocytes are the most numerous glial cells in the central nervous system and, under physiological conditions, protect neurons from oxidative damage. However, it is uncertain how their reactive phenotype may affect motor neurons during ALS progression. In two different ALS mouse models (SOD1G93A and FUS-R521C), we found that increased levels of proinflammatory interleukin 6 facilitate glutathione (GSH) release from the liver to blood circulation, which can reach the astrocytes and be channeled towards motor neurons as a mechanism of antioxidant protection. Nevertheless, although ALS progression is associated with an increase in GSH efflux from astrocytes, generation of reactive oxygen species also increases, suggesting that as the disease progresses, astrocyte-derived oxidative stress could be key to motor-neuron damage.
dc.language.iso	eng
dc.relation.ispartof	Antioxidants, 2021, vol. 10, p. 2007
dc.subject	Esclerosi múltiple
dc.subject	Neurones
dc.subject	Sistema nerviós central Malalties
dc.title	An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis
dc.type	journal article	es_ES
dc.date.updated	2021-12-20T17:19:03Z
dc.identifier.doi	10.3390/antiox10122007
dc.identifier.idgrec	149395
dc.rights.accessRights	open access	es_ES