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Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

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Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2

dc.contributor.author	Ferrer, María D.
dc.contributor.author	Sánchez Barrueco, Álvaro
dc.contributor.author	Martínez Beneyto, Yolanda
dc.contributor.author	Mateos Moreno, María Victoria
dc.contributor.author	Ausina Márquez, Verónica
dc.contributor.author	García Vázquez, Elisa
dc.contributor.author	Puche Torres, Miguel
dc.contributor.author	Forner Giner, María José
dc.contributor.author	Campos González, Alfonso
dc.contributor.author	Santillán Coello, Jessica
dc.contributor.author	Alcalá Rueda, Ignacio
dc.contributor.author	Villacampa Aubá, José M.
dc.contributor.author	Cenjor Español, Carlos
dc.contributor.author	López Velasco, Ana
dc.contributor.author	Santolaya Abad, Diego
dc.contributor.author	García Esteban, Sandra
dc.contributor.author	Artacho, Alejandro
dc.contributor.author	López Labrador, Francesc Xavier
dc.contributor.author	Mira, Alex
dc.date.accessioned	2022-01-11T15:20:17Z
dc.date.available	2022-01-11T15:20:17Z
dc.date.issued	2021
dc.identifier.citation	Ferrer, María D. Sánchez Barrueco, Álvaro Martínez Beneyto, Yolanda Mateos Moreno, María Victoria Ausina Márquez, Verónica García Vázquez, Elisa Puche Torres, Miguel Forner Giner, María José Campos González, Alfonso Santillán Coello, Jessica Alcalá Rueda, Ignacio Villacampa Aubá, José M. Cenjor Español, Carlos López Velasco, Ana Santolaya Abad, Diego García Esteban, Sandra Artacho, Alejandro López Labrador, Francesc Xavier Mira, Alex 2021 Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2 Scientific Reports
dc.identifier.uri	https://hdl.handle.net/10550/81301
dc.description.abstract	Most public health measures to contain the COVID-19 pandemic are based on preventing the pathogen spread, and the use of oral antiseptics has been proposed as a strategy to reduce transmission risk. The aim of this manuscript is to test the efficacy of mouthwashes to reduce salivary viral load in vivo. This is a multi-centre, blinded, parallel-group, placebo-controlled randomised clinical trial that tests the effect of four mouthwashes (cetylpyridinium chloride, chlorhexidine, povidone-iodine and hydrogen peroxide) in SARS-CoV-2 salivary load measured by qPCR at baseline and 30, 60 and 120 min after the mouthrinse. A fifth group of patients used distilled water mouthrinse as a control. Eighty-four participants were recruited and divided into 12-15 per group. There were no statistically significant changes in salivary viral load after the use of the different mouthwashes. Although oral antiseptics have shown virucidal effects in vitro, our data show that salivary viral load in COVID-19 patients was not affected by the tested treatments. This could reflect that those mouthwashes are not effective in vivo, or that viral particles are not infective but viral RNA is still detected by PCR. Viral infectivity studies after the use of mouthwashes are therefore required.
dc.language.iso	eng
dc.relation.ispartof	Scientific Reports, 2021
dc.subject	Virus
dc.subject	Malalties transmissibles Prevenció
dc.title	Clinical evaluation of antiseptic mouth rinses to reduce salivary load of SARS-CoV-2
dc.type	journal article	es_ES
dc.date.updated	2022-01-11T15:20:18Z
dc.identifier.doi	10.1038/s41598-021-03461-y
dc.identifier.idgrec	149558
dc.rights.accessRights	open access	es_ES