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In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review

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In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review

dc.contributor.author	Frangiamone, Massimo
dc.contributor.author	Cimbalo, Alessandra
dc.contributor.author	Alonso-Garrido, Manuel
dc.contributor.author	Vila Donat, Pilar
dc.contributor.author	Manyes Font, Lara
dc.date.accessioned	2022-01-14T14:36:38Z
dc.date.available	2022-01-14T14:36:38Z
dc.date.issued	2022
dc.identifier.citation	Frangiamone, Massimo Cimbalo, Alessandra Alonso-Garrido, Manuel Vila Donat, Pilar Manyes Font, Lara 2022 In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review Food and Chemical Toxicology 160 112798
dc.identifier.uri	https://hdl.handle.net/10550/81329
dc.description.abstract	Due to the globalization, mycotoxins have been considered a major risk to human health being the main con- taminants of foodstuffs. Among them, AFB1 and OTA are the most toxic and studied. Therefore, the goal of this review is to deepen the knowledge about the toxicological effects that AFB1 and OTA can induce on human health by using flow cytometry and immunofluorescence techniques in vitro and in vivo models. The examination of the selected reports shows that the majority of them are focused on immunotoxicity while the rest are con- cerned about nephrotoxicity, hepatotoxicity, gastrointestinal toxicity, neurotoxicity, embryotoxicity, reproduc- tive system, breast, esophageal and lung toxicity. In relation to immunofluorescence analysis, biological processes related to AFB1- and OTA-toxicity were evaluated such as inflammation, neuronal differentiation, DNA damage, oxidative stress and cell death. In flow cytometry analysis, a wide range of assays have been performed across the reviewed studies being apoptosis assay, cell cycle analysis and intracellular ROS measurement the most employed. Although, the toxic effects of AFB1 and OTA have been reported, further research is needed to clarify AFB1 and OTA-mechanism of action on human health.
dc.language.iso	eng
dc.relation.ispartof	Food and Chemical Toxicology, 2022, vol. 160, p. 112798
dc.subject	Salut pública
dc.subject	Salut
dc.subject	Aliments Contaminació
dc.subject	Aliments Toxicologia
dc.title	In vitro and in vivo evaluation of AFB1 and OTA-toxicity through immunofluorescence and flow cytometry techniques : A systematic review
dc.type	journal article	es_ES
dc.date.updated	2022-01-14T14:36:38Z
dc.identifier.doi	10.1016/j.fct.2021.112798
dc.identifier.idgrec	149675
dc.rights.accessRights	open access	es_ES