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Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction

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Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction

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dc.contributor.author	Fernández Rodríguez, Sandra
dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Rius Pérez, Sergio
dc.contributor.author	Pérez Garrido, Salvador
dc.contributor.author	Guerri Sirera, Consuelo
dc.contributor.author	Granero Maciá, Luis
dc.contributor.author	Zornoza Sabina, Teodoro
dc.contributor.author	Polache Vengut, Ana
dc.date.accessioned	2022-02-09T15:08:57Z
dc.date.available	2022-02-09T15:08:57Z
dc.date.issued	2022
dc.identifier.citation	Fernández Rodríguez, Sandra Cano Cebrián, María José Rius Pérez, Sergio Pérez Garrido, Salvador Guerri Sirera, Consuelo Granero Maciá, Luis Zornoza Sabina, Teodoro Polache Vengut, Ana 2022 Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction Drug and Alcohol Dependence 232 109284
dc.identifier.uri	https://hdl.handle.net/10550/81556
dc.description.abstract	Rationale: Accumulating evidence suggests that chronic alcohol consumption is associated with excessive oxidative damage and neuroinflammatory processes and these events have been associated to early alcohol withdrawal. In the present research we wonder if brain oxidative stress and neuroinflammation remains altered during prolonged withdrawal situations and whether these alterations can be correlated with relapse behavior in alcohol consumption. The effects of alcohol reintroduction were also evaluated. Methods: We have used a model based on the alcohol deprivation effect (ADE) within a cohort of wild-type male Wistar rats. Two subpopulations were identified according to the alcohol relapse-like drinking behavior displayed (ADE and NO-ADE subpopulations). Oxidized and reduced glutathione content was determined within the hippocampus and the amygdala using a mass spectrometry method. The levels of mRNA of seven different inflammatory mediators in the prefrontal cortex of rats were quantified. All the analyses were performed in two different conditions: after 21-day alcohol deprivation (prolonged abstinence) and after 24 h of ethanol reintroduction in both subpopulations. Results: ADE and NO-ADE rats showed different endophenotypes. ADE rats always displayed a significant lower alcohol intake rate and ethanol preference than NO-ADE rats. The results also demonstrated the existence of altered brain redox and neuroinflammation status after prolonged abstinence exclusively in ADE rats. Moreover, when ethanol was reintroduced in the ADE subpopulation, altered oxidative stress and neuroinflammatory markers were restored. Conclusions: Present findings provide new mechanisms underlying the neurobiology of relapse behavior and suggest the development of new pharmacological approaches to treat alcohol-induced relapse.
dc.language.iso	eng
dc.relation.ispartof	Drug and Alcohol Dependence, 2022, vol. 232, p. 109284
dc.subject	Estrès oxidatiu
dc.subject	Alcohol Efectes fisiològics
dc.title	Different brain oxidative and neuroinflammation status in rats during prolonged abstinence depending on their ethanol relapse-like drinking behavior: Effects of ethanol reintroduction
dc.type	journal article	es_ES
dc.date.updated	2022-02-09T15:08:57Z
dc.identifier.doi	10.1016/j.drugalcdep.2022.109284
dc.identifier.idgrec	150232
dc.rights.accessRights	open access	es_ES