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Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats

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Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats

dc.contributor.author	Cano Cebrián, María José
dc.contributor.author	Fernández Rodríguez, Sandra
dc.contributor.author	Hipólito Cubedo, Lucía
dc.contributor.author	Granero Maciá, Luis
dc.contributor.author	Polache Vengut, Ana
dc.contributor.author	Zornoza Sabina, Teodoro
dc.date.accessioned	2022-02-11T08:41:20Z
dc.date.available	2022-02-12T05:45:05Z
dc.date.issued	2021	es_ES
dc.identifier.citation	Cano-Cebrián MJ, Fernández-Rodríguez S, Hipólito L, Granero L, Polache A, Zornoza T. Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats. J Neurosci Res. 2021 Feb;99(2):638-648.	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/81571
dc.description.abstract	Alcohol use disorders are chronic and highly relapsing disorders, thus alcoholic patients have a high rate of recidivism for drug use even after long periods of abstinence. The literature points to the potential usefulness of N-acetylcysteine (NAC) in the management of several substance use disorders probably due to its capacity to restore brain homeostasis of the glutamate system disrupted in addiction. However, there is little evidence in the case of alcohol. The aim of this study was to explore the potential anti-relapse efficacy of NAC using the alcohol deprivation effect (ADE) model in long-term experienced rats. Two experiments were performed in male Wistar rats to: (a) test the efficacy of NAC to prevent relapse and (b) discriminate the best administration schedule (intermittent vs. continuous) for NAC. In the first experiment, animals were implanted with mini-osmotic pumps delivering 0 or 1 mg/hr NAC during 14 days. In a second experiment, rats received 0, 60, or 100 mg/kg once daily by subcutaneous injection. The efficacy to prevent ADE was evaluated in both experiments. NAC subcutaneously administered, either by continuous infusion or by intermittent injections regimen, is able to block the ADE. The best results were obtained after using 60 mg/kg NAC dose. Our findings support the hypothesis that NAC may represent a valuable therapy in the management of alcohol relapse.	es_ES
dc.description.sponsorship	Generalitat Valenciana	es_ES
dc.language.iso	en	es_ES
dc.subject	alcohol use disorders	es_ES
dc.subject	ethanol relapse prevention	es_ES
dc.subject	glutamate neurotransmission	es_ES
dc.subject	alcohol deprivation effec	es_ES
dc.title	Efficacy of N-acetylcysteine in the prevention of alcohol relapse-like drinking: Study in long-term ethanol-experienced male rats	es_ES
dc.type	journal article	es_ES
dc.subject.unesco	UNESCO::CIENCIAS DE LA VIDA	es_ES
dc.identifier.doi	10.1002/jnr.24736	es_ES
dc.identifier.idgrec	140883	es_ES
dc.accrualmethod	-	es_ES
dc.embargo.terms	0 days	es_ES
dc.relation.projectID	GVA/2016/096