NAGIOS: RODERIC FUNCIONANDO

Folding and insertion of transmembrane helices at the ER

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Folding and insertion of transmembrane helices at the ER

dc.contributor.author	Whitley, Paul
dc.contributor.author	Grau, Brayan
dc.contributor.author	Gumbart, James C.
dc.contributor.author	Martínez Gil, Luis
dc.contributor.author	Mingarro Muñoz, Ismael
dc.date.accessioned	2022-03-07T18:03:19Z
dc.date.available	2022-03-07T18:03:19Z
dc.date.issued	2021
dc.identifier.citation	Whitley, Paul Grau, Brayan Gumbart, James C. Martínez Gil, Luis Mingarro Muñoz, Ismael 2021 Folding and insertion of transmembrane helices at the ER International Journal Of Molecular Sciences 22 12778
dc.identifier.uri	https://hdl.handle.net/10550/81843
dc.description.abstract	In eukaryotic cells, the endoplasmic reticulum (ER) is the entry point for newly synthesized proteins that are subsequently distributed to organelles of the endomembrane system. Some of these proteins are completely translocated into the lumen of the ER while others integrate stretches of amino acids into the greasy 30 Å wide interior of the ER membrane bilayer. It is generally accepted that to exist in this non-aqueous environment the majority of membrane integrated amino acids are primarily non-polar/hydrophobic and adopt an α-helical conformation. These stretches are typically around 20 amino acids long and are known as transmembrane (TM) helices. In this review, we will consider how transmembrane helices achieve membrane integration. We will address questions such as: Where do the stretches of amino acids fold into a helical conformation? What is/are the route/routes that these stretches take from synthesis at the ribosome to integration through the ER translocon? How do these stretches 'know' to integrate and in which orientation? How do marginally hydrophobic stretches of amino acids integrate and survive as transmembrane helices?
dc.language.iso	eng
dc.relation.ispartof	International Journal Of Molecular Sciences, 2021, vol. 22, num. 12778
dc.subject	Proteïnes de membrana
dc.subject	Ribosomes
dc.title	Folding and insertion of transmembrane helices at the ER
dc.type	journal article	es_ES
dc.date.updated	2022-03-07T18:03:20Z
dc.identifier.doi	10.3390/ijms222312778
dc.identifier.idgrec	150228
dc.rights.accessRights	open access	es_ES