NAGIOS: RODERIC FUNCIONANDO

Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli

Repositori DSpace/Manakin

Valencià Castellano

Inici
Investigació
e-prints
23 - Química
Visualitza element

IMPORTANT: Aquest repositori està en una versió antiga des del 3/12/2023. La nova instal.lació está en https://roderic.uv.es/

Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli

Mostra el registre parcial de l'element

dc.contributor.author	Tiburcio, Estefanía
dc.contributor.author	García-Junceda, Eduardo
dc.contributor.author	Garrido, Leoncio
dc.contributor.author	Fernández-Mayoralas, Alfonso
dc.contributor.author	Revuelta, Julia
dc.contributor.author	Bastida, Agatha
dc.date.accessioned	2022-03-10T13:36:27Z
dc.date.available	2022-03-10T13:36:27Z
dc.date.issued	2021
dc.identifier.citation	Tiburcio, Estefanía García-Junceda, Eduardo Garrido, Leoncio Fernández-Mayoralas, Alfonso Revuelta, Julia Bastida, Agatha 2021 Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli Polymers 13 19 3326
dc.identifier.uri	https://hdl.handle.net/10550/81897
dc.description.abstract	Although aminoglycosides are one of the common classes of antibiotics that have been widely used for treating infections caused by pathogenic bacteria, the evolution of bacterial resistance mechanisms and their inherent toxicity have diminished their applicability. Biocompatible carrier systems can help sustain and control the delivery of antibacterial compounds while reducing the chances of antibacterial resistance or accumulation in unwanted tissues. In this study, novel chitosan gel beads were synthesized by a double ionic co-crosslinking mechanism. Tripolyphosphate and alginate, a polysaccharide obtained from marine brown algae, were employed as ionic cross-linkers to prepare the chitosan-based networks of gel beads. The in vitro release of streptomycin and kanamycin A was bimodal; an initial burst release was observed followed by a diffusion mediated sustained release, based on a Fickian diffusion mechanism. Finally, in terms of antibacterial properties, the particles resulted in growth inhibition of Gram-negative (E. coli) bacteria.
dc.language.iso	eng
dc.relation.ispartof	Polymers, 2021, vol. 13, num. 19, p. 3326
dc.subject	Antibiòtics
dc.subject	Biomolècules
dc.title	Preparation and Characterization of Aminoglycoside-Loaded Chitosan/Tripolyphosphate/Alginate Microspheres against E. coli
dc.type	journal article	es_ES
dc.date.updated	2022-03-10T13:36:28Z
dc.identifier.doi	10.3390/polym13193326
dc.identifier.idgrec	150596
dc.rights.accessRights	open access	es_ES