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Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice

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Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice

dc.contributor.author	Olivares González, Lorena
dc.contributor.author	Velasco Gomariz, Sheyla
dc.contributor.author	Campillo, Isabel
dc.contributor.author	Salom Alonso, David
dc.contributor.author	González-García, Emilio
dc.contributor.author	Soriano del Castillo, José Miguel
dc.contributor.author	Rodrigo, Regina
dc.date.accessioned	2022-03-22T14:43:21Z
dc.date.available	2022-03-22T14:43:21Z
dc.date.issued	2021
dc.identifier.citation	Olivares González, Lorena Velasco Gomariz, Sheyla Campillo, Isabel Salom Alonso, David González-García, Emilio Soriano del Castillo, José Miguel Rodrigo, Regina 2021 Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice Antioxidants 10 7 1033
dc.identifier.uri	https://hdl.handle.net/10550/81992
dc.description.abstract	Retinitis pigmentosa (RP) is a group of inherited retinal dystrophies characterized by progressive degeneration of photoreceptor cells. Ocular redox status is altered in RP suggesting oxidative stress could contribute to their progression. In this study, we investigated the effect of a mixture of nutraceuticals with antioxidant properties (NUT) on retinal degeneration in rd10 mice, a model of RP. NUT was orally administered to rd10 mice from postnatal day (PD) 9 to PD18. At PD18 retinal function and morphology were examined by electroretinography (ERG) and histology including TUNEL assay, immunolabeling of microglia, Müller cells, and poly ADP ribose polymers. Retinal redox status was determined by measuring the activity of antioxidant enzymes and some oxidative stress markers. Gene expression of the cytokines IL-6, TNFα, and IL-1β was assessed by real-time PCR. NUT treatment delayed the loss of photoreceptors in rd10 mice partially preserving their electrical responses to light stimuli. Moreover, it ameliorated redox status and reduced inflammation including microglia activation, upregulation of cytokines, reactive gliosis, and PARP overactivation. NUT ameliorated retinal functionality and morphology at early stages of RP in rd10 mice. This formulation could be useful as a neuroprotective approach for patients with RP in the future.
dc.language.iso	eng
dc.relation.ispartof	Antioxidants, 2021, vol. 10, num. 7, p. 1033
dc.subject	Ulls Inflamació
dc.subject	Nutrició
dc.subject	Antioxidants
dc.title	Nutraceutical Supplementation Ameliorates Visual Function, Retinal Degeneration, and Redox Status in rd10 Mice
dc.type	journal article	es_ES
dc.date.updated	2022-03-22T14:43:21Z
dc.identifier.doi	10.3390/antiox10071033
dc.identifier.idgrec	150672
dc.rights.accessRights	open access	es_ES