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Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development

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Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development

dc.contributor.author	Borrell, Sònia
dc.contributor.author	Trauner, Andrej
dc.contributor.author	Brites, Daniela
dc.contributor.author	Rigouts, Leen
dc.contributor.author	Loiseau, Chloe
dc.contributor.author	Coscollá, Mireia
dc.contributor.author	Niemann, Stefan
dc.contributor.author	De Jong, Bouke
dc.contributor.author	Yeboah-Manu, Dorothy
dc.contributor.author	Kato-Maeda, Midori
dc.contributor.author	Feldmann, Julia
dc.contributor.author	Reinhard, Miriam
dc.contributor.author	Beisel, Christian
dc.contributor.author	Gagneux, Sebastien
dc.date.accessioned	2022-03-23T14:43:07Z
dc.date.available	2022-03-23T14:43:07Z
dc.date.issued	2019
dc.identifier.citation	Borrell, Sònia Trauner, Andrej Brites, Daniela Rigouts, Leen Loiseau, Chloe Coscollá, Mireia Niemann, Stefan De Jong, Bouke Yeboah-Manu, Dorothy Kato-Maeda, Midori Feldmann, Julia Reinhard, Miriam Beisel, Christian Gagneux, Sebastien 2019 Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development Plos One 14 3 e0214088
dc.identifier.uri	https://hdl.handle.net/10550/82009
dc.description.abstract	The Mycobacterium tuberculosis complex (MTBC) causes tuberculosis (TB) in humans and various other mammals. The human-adapted members of the MTBC comprise seven phylogenetic lineages that differ in their geographical distribution. There is growing evidence that this phylogeographic diversity modulates the outcome of TB infection and disease. For decades, TB research and development has focused on the two canonical MTBC laboratory strains H37Rv and Erdman, both of which belong to Lineage 4. Relying on only a few laboratory-adapted strains can be misleading as study results might not be directly transferrable to clinical settings where patients are infected with a diverse array of strains, including drug-resistant variants. Here, we argue for the need to expand TB research and development by incorporating the phylogenetic diversity of the MTBC. To facilitate such work, we have assembled a group of 20 genetically well-characterized clinical strains representing the seven known human-adapted MTBC lineages. With the "MTBC clinical strains reference set" we aim to provide a standardized resource for the TB community. We hope it will enable more direct comparisons between studies that explore the physiology of MTBC beyond the laboratory strains used thus far. We anticipate that detailed phenotypic analyses of this reference strain set will increase our understanding of TB biology and assist in the development of new control tools that are broadly effective.
dc.language.iso	eng
dc.relation.ispartof	Plos One, 2019, vol. 14, num. 3, p. e0214088
dc.subject	Tuberculosi
dc.subject	Genòmica
dc.title	Reference set of Mycobacterium tuberculosis clinical strains: A tool for research and product development
dc.type	journal article	es_ES
dc.date.updated	2022-03-23T14:43:08Z
dc.identifier.doi	10.1371/journal.pone.0214088
dc.identifier.idgrec	130821
dc.rights.accessRights	open access	es_ES