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Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy

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Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy

dc.contributor.author	Herrera, Lara
dc.contributor.author	Martin-Inaraja, Myriam
dc.contributor.author	Santos, Silvia
dc.contributor.author	Ingles-Ferrandiz, Marta
dc.contributor.author	Azkarate, Aida
dc.contributor.author	Perez-Vaquero, Miguel A.
dc.contributor.author	Vesga, Miguel A.
dc.contributor.author	Vicario, Jose L.
dc.contributor.author	Soria, Bernat
dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	De Paz, Raquel
dc.contributor.author	Marcos, Antonio
dc.contributor.author	Ferreras, Cristina
dc.contributor.author	Perez-Martinez, Antonio
dc.contributor.author	Eguizabal, Cristina
dc.date.accessioned	2022-03-29T06:46:42Z
dc.date.available	2022-03-29T06:46:42Z
dc.date.issued	2022
dc.identifier.citation	Herrera, Lara Martin-Inaraja, Myriam Santos, Silvia Ingles-Ferrandiz, Marta Azkarate, Aida Perez-Vaquero, Miguel A. Vesga, Miguel A. Vicario, Jose L. Soria, Bernat Solano Vercet, Carlos De Paz, Raquel Marcos, Antonio Ferreras, Cristina Perez-Martinez, Antonio Eguizabal, Cristina 2022 Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy Immunology 165 2 234 259
dc.identifier.uri	https://hdl.handle.net/10550/82065
dc.description.abstract	COVID-19 disease is the manifestation of syndrome coronavirus 2 (SARS-CoV-2) infection, which is causing a worldwide pandemic. This disease can lead to multiple and different symptoms, being lymphopenia associated with severity one of the most persistent. Natural killer cells (NK cells) are part of the innate immune system, being fighting against virus-infected cells one of their key roles. In this study, we determined the phenotype of NK cells after COVID-19 and the main characteristic of SARS-CoV-2-specific-like NK population in the blood of convalescent donors. CD57+ NKG2C+ phenotype in SARS-CoV-2 convalescent donors indicates the presence of 'memory'/activated NK cells as it has been shown for cytomegalovirus infections. Although the existence of this population is donor dependent, its expression may be crucial for the specific response against SARS-CoV-2, so that, it gives us a tool for selecting the best donors to produce off-the-shelf living drug for cell therapy to treat COVID-19 patients under the RELEASE clinical trial (NCT04578210).
dc.language.iso	eng
dc.relation.ispartof	Immunology, 2022, vol. 165, num. 2, p. 234-259
dc.subject	Cèl·lules
dc.title	Identifying SARS-CoV-2 'memory' NK cells from COVID-19 convalescent donors for adoptive cell therapy
dc.type	journal article	es_ES
dc.date.updated	2022-03-29T06:46:43Z
dc.identifier.doi	10.1111/imm.13432
dc.identifier.idgrec	150864
dc.rights.accessRights	open access	es_ES