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Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients

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Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients

dc.contributor.author	Torres, Ignacio
dc.contributor.author	Huntley, Dixie
dc.contributor.author	Tormo, Mar
dc.contributor.author	Calabuig, Marisa
dc.contributor.author	Hernández-Boluda, Juan Carlos
dc.contributor.author	Terol, Maria José
dc.contributor.author	Carretero, Carlos
dc.contributor.author	de Michelena, Paula
dc.contributor.author	Pérez, Ariadna
dc.contributor.author	Piñana, José Luis
dc.contributor.author	Colomina, Javier
dc.contributor.author	Solano Vercet, Carlos
dc.contributor.author	Navarro, David
dc.date.accessioned	2022-03-29T08:46:16Z
dc.date.available	2022-03-29T08:46:16Z
dc.date.issued	2022
dc.identifier.citation	Torres, Ignacio Huntley, Dixie Tormo, Mar Calabuig, Marisa Hernández-Boluda, Juan Carlos Terol, Maria José Carretero, Carlos de Michelena, Paula Pérez, Ariadna Piñana, Jose Luis Colomina, Javier Solano Vercet, Carlos Navarro, David 2022 Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients BMC Infectious Diseases 22 1
dc.identifier.uri	https://hdl.handle.net/10550/82071
dc.description.abstract	Background To investigate the multi-drug resistant bacteria (MDRB) colonization rate in hematological patients hospitalized for any cause using a multi-body-site surveillance approach, and determine the extent to which this screening strategy helped anticipate MDRB bloodstream infections (BSI). Methods Single-center retrospective observational study including 361 admissions documented in 250 adult patients. Surveillance cultures of nasal, pharyngeal, axillary and rectal specimens (the latter two combined) were performed at admission and subsequently on a weekly basis. Blood culture samples were incubated in an automated continuous monitoring blood culturing instrument (BACTEC FX). Results In total, 3463 surveillance cultures were performed (pharyngeal, n = 1201; axillary-rectal, n = 1200; nasal, n = 1062). MDRB colonization was documented in 122 out of 361 (33.7%) admissions corresponding to 86 patients (34.4%). A total of 149 MDRB were isolated from one or more body sites, of which most were Gram-negative bacteria, most frequently non-fermenting (n = 83) followed by Enterobacterales (n = 51). BSI were documented in 102 admissions (28%) involving 87 patients. Overall, the rate of BSI caused by MDRB was significantly higher (p = 0.04) in the presence of colonizing MDRB (16 out of 47 admissions in 14 patients) than in its absence (9 out of 55 admissions in 9 patients). Colonization by any MDRB was independently associated with increased risk of MDRB-BSI (HR, 3.70; 95% CI, 1.38-9.90; p = 0.009). Conclusion MDRB colonization is a frequent event in hematological patients hospitalized for any reason and is associated with an increased risk of MDRB BSI. The data lend support to the use of MDRB colonization surveillance cultures for predicting the occurrence of MDRB BSI in this cohort.
dc.language.iso	eng
dc.relation.ispartof	BMC Infectious Diseases, 2022, vol. 22, num. 1
dc.subject	Medicina
dc.title	Multi-body-site colonization screening cultures for predicting multi-drug resistant Gram-negative and Gram-positive bacteremia in hematological patients
dc.type	journal article	es_ES
dc.date.updated	2022-03-29T08:46:16Z
dc.identifier.doi	10.1186/s12879-022-07154-3
dc.identifier.idgrec	150862
dc.rights.accessRights	open access	es_ES