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Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes.

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Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes.

dc.contributor.author	Heerlein, K.
dc.contributor.author	Perugi, G.
dc.contributor.author	Otte, C.
dc.contributor.author	Frodl, T.
dc.contributor.author	Degraeve, G.
dc.contributor.author	Hagedoorn, W.
dc.contributor.author	Oliveira-Maia, A.J.
dc.contributor.author	Pérez Solá, V.
dc.contributor.author	Rathod, S.
dc.contributor.author	Rosso, G.
dc.contributor.author	Sierra, Pilar
dc.contributor.author	Malynn, S.
dc.contributor.author	Morrens, J.
dc.contributor.author	Verrijcken, C.
dc.contributor.author	Gonzalez, B.
dc.contributor.author	Young, A.H.
dc.date.accessioned	2022-04-05T08:30:29Z
dc.date.available	2022-04-05T08:30:29Z
dc.date.issued	2021
dc.identifier.citation	Heerlein, K. Perugi, G. Otte, C. Frodl, T. Degraeve, G. Hagedoorn, W. Oliveira-Maia, A.J. Perez Sola, V. Rathod, S. Rosso, G. Sierra, Pilar Malynn, S. Morrens, J. Verrijcken, C. Gonzalez, B. Young, A.H. 2021 Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes. Journal of Affective Disorders 1 290 334 344
dc.identifier.uri	https://hdl.handle.net/10550/82155
dc.description.abstract	Background: Treatment resistant depression (TRD) characterizes a subgroup of 10-30% of patients with major depressive disorder, and is associated with considerable morbidity and mortality. A consensus treatment for TRD does not exist, which often leads to wide variations in treatment strategies. Real-world studies on treatment patterns and outcomes in TRD patients in Europe are lacking and could help elucidate current treatment strategies and their efficacy. Methods: This non-interventional cohort study of patients with TRD (defined as treatment failure on ≥2 oral antidepressants given at adequate dose and duration) with moderate to severe depression collected real-world data on treatment patterns and outcomes in several European countries. Patients were started on a new treatment for depression according to routine clinical practice. Results: Among 411 patients enrolled, after 6 months, only 16.7% achieved remission and 73.5% showed no response. At Month 12, while 19.2% achieved remission and 69.2% showed no response, 33.3% of those in remission at Month 6 were no longer in remission. Pharmacological treatments employed were heterogenous; 54 different drugs were recorded at baseline, and the top 5 treatment types according to drug classes accounted for 40.0% of patients. Even though remission rates were very low, at Month 12, 60.0% of patients had not changed treatment since enrolment. Conclusions: The heterogeneity of treatments highlights a lack of consensus. Moreover, despite low response rates, patients often remained on treatments for substantial periods of time. These data further support existence of an unmet treatment need for TRD patients in Europe.
dc.language.iso	eng
dc.relation.ispartof	Journal of Affective Disorders, 2021, vol. 1, num. 290, p. 334-344
dc.subject	Psiquiatria
dc.title	Real-world evidence from a European cohort study of patients with treatment resistant depression: Treatment patterns and clinical outcomes.
dc.type	journal article	es_ES
dc.date.updated	2022-04-05T08:30:29Z
dc.identifier.doi	10.1016/j.jad.2021.03.073
dc.identifier.idgrec	151163
dc.rights.accessRights	open access	es_ES