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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

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Oxytocin prevents the increase of cocaine-related responses produced by social defeat

dc.contributor.author	Ferrer-Pérez, Carmen
dc.contributor.author	Castro-Zavala, Adriana
dc.contributor.author	Luján, Miguel Ángel
dc.contributor.author	Filarowska, Joanna
dc.contributor.author	Ballestín, Raúl
dc.contributor.author	Miñarro López, José
dc.contributor.author	Valverde, Olga
dc.contributor.author	Arenas, M.Carmen
dc.contributor.author	Manzanedo Pérez, Carmen
dc.contributor.author	Rodríguez-Árias, Marta
dc.date.accessioned	2022-04-07T11:50:58Z
dc.date.available	2022-04-08T04:45:05Z
dc.date.issued	2018	es_ES
dc.identifier.citation	Póster 2018-10-05 Reunión RTA Barcelona	es_ES
dc.identifier.uri	https://hdl.handle.net/10550/82220
dc.description.abstract	The neuropeptide oxytocin (OXT) plays a critical role in the regulation of social and emotional behaviors. OXT plays a role in the stress response and in drug reward, but to date no studies have evaluated its implication in the long-lasting increase of the motivational effects of cocaine induced by repeated social defeat (SD). During the social defeat procedure, 1 mg/kg of OXT was administered 30 minutes before each episode of SD. Three weeks after the last defeat, the effects of cocaine on conditioned place preference (CPP), locomotor sensitization and the self-administration (SA) paradigm were evaluated. Our results confirm that raising the levels of OXT during social defeat stress can block the long-lasting effects of this type of stress. OXT counteracts the anxiety induced by SD. Moreover, OXT prevents SD-induced increases in the motivational effects of cocaine. Administration of OXT before each social defeat blocked the SD-induced increment in the conditioned rewarding effects of cocaine in the CPP, favors the extinction of cocaine-associated memories in both the CPP and SA, and decreases reinstatement of cocaine-seeking behavior in the SA. In conclusion, the long-lasting effects of SD are counteracted by administering OXT prior to stress.	es_ES
dc.language.iso	es	es_ES
dc.title	Oxytocin prevents the increase of cocaine-related responses produced by social defeat	es_ES
dc.type	conference output	es_ES
dc.subject.unesco	UNESCO::PSICOLOGÍA	es_ES
dc.accrualmethod	-	es_ES
dc.embargo.terms	0 days	es_ES
dc.relation.projectID	Prometeo/2018/132	es_ES