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Application of a Low Transition Temperature Mixture for the Dispersive Liquid-Liquid Microextraction of Illicit Drugs from Urine Samples

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Application of a Low Transition Temperature Mixture for the Dispersive Liquid-Liquid Microextraction of Illicit Drugs from Urine Samples

dc.contributor.author	Gallo, Valeria
dc.contributor.author	Tomai, Pierpaolo
dc.contributor.author	Di Lisio, Valerio
dc.contributor.author	Dal Bosco, Chiara
dc.contributor.author	D'Angelo, Paola
dc.contributor.author	Fanali, Chiara
dc.contributor.author	D'orazio, Giovanni
dc.contributor.author	Silvestro, Ilaria
dc.contributor.author	Picó García, Yolanda
dc.contributor.author	Gentili, Alessandra
dc.date.accessioned	2022-04-11T12:40:26Z
dc.date.available	2022-04-11T12:40:26Z
dc.date.issued	2021
dc.identifier.citation	Gallo, Valeria Tomai, Pierpaolo Di Lisio, Valerio Dal Bosco, Chiara D'Angelo, Paola Fanali, Chiara D'orazio, Giovanni Silvestro, Ilaria Picó García, Yolanda Gentili, Alessandra 2021 Application of a Low Transition Temperature Mixture for the Dispersive Liquid-Liquid Microextraction of Illicit Drugs from Urine Samples Molecules 26 17 5222
dc.identifier.uri	https://hdl.handle.net/10550/82275
dc.description.abstract	The use of psychoactive substances is a serious problem in today's society and reliable methods of analysis are necessary to confirm their occurrence in biological matrices. In this work, a green sample preparation technique prior to HPLC-MS analysis was successfully applied to the extraction of 14 illicit drugs from urine samples. The isolation procedure was a dispersive liquid-liquid microextraction based on the use of a low transition temperature mixture (LTTM), composed of choline chloride and sesamol in a molar ratio 1:3 as the extracting solvent. This mixture was classified as LTTM after a thorough investigation carried out by FTIR and DSC, which recorded a glass transition temperature at −71 °C. The extraction procedure was optimized and validated according to the main Food and Drug Administration (FDA) guidelines for bioanalytical methods, obtaining good figures of merit for all parameters: the estimated lower limit of quantitation (LLOQ) values were between 0.01 µg L−1 (bk-MMBDB) and 0.37 µg L−1 (PMA); recoveries, evaluated at very low spike levels (in the ng-µg L−1 range), spanned from 55% (MBDB) to 100% (bk-MMBDB and MDPV); finally, both within-run and between-run precisions were lower than 20% (LLOQ) and 15% (10xLLOQ).
dc.language.iso	eng
dc.relation.ispartof	Molecules, 2021, vol. 26, num. 17, p. 5222
dc.subject	Drogues
dc.subject	Productes biològics
dc.title	Application of a Low Transition Temperature Mixture for the Dispersive Liquid-Liquid Microextraction of Illicit Drugs from Urine Samples
dc.type	journal article	es_ES
dc.date.updated	2022-04-11T12:40:27Z
dc.identifier.doi	10.3390/molecules26175222
dc.identifier.idgrec	151370
dc.rights.accessRights	open access	es_ES